Neutralizing antibodies (Nab) are a principal component of an effective human immune
response to many pathogens, yet their role in HIV-1 infection is unclear 1 , 2 , 3 , 4 , 5 , 6 . To gain …

The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for
productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 …

Identification of full-length transmitted HIV-1 genomes could be instrumental in HIV-1
pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those viruses …

Background Tumor-associated macrophages (TAMs) are major components of tumor
microenvironment that frequently associated with tumor metastasis in human cancers. Circulating …

Impaired cardiac microvascular function contributes to diabetic cardiovascular complications
although effective therapy remains elusive. Empagliflozin, a sodium-glucose cotransporter …

It is generally assumed that polymeric micelles, upon administration into the blood stream,
carry drug molecules until they are taken up into cells followed by intracellular release. The …

Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of
one gene depends on the presence of a second, have enabled the systematic exploration of …

The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point, epidemiological, …

Immunogenic, broadly reactive epitopes of the HIV-1 envelope glycoprotein could serve as
important targets of the adaptive humoral immune response in natural infection and, …

We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions
targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected …