During apoptosis, the mitochondrial network fragments. Using short hairpin RNAs for RNA
interference, we manipulated the expression levels of the proteins hFis1, Drp1, and Opa1 that …

We find that Bax, a proapoptotic member of the Bcl-2 family, translocates to discrete foci on
mitochondria during the initial stages of apoptosis, which subsequently become …

Bcl-2 family proteins are potent regulators of programmed cell death. Although their intracellular
localization to mitochondria and the endoplasmic reticulum has focused research on …

Apoptosis (programmed cell death) is a cellular self-destruction mechanism that is essential
for a variety of biological events, such as developmental sculpturing, tissue homeostasis, …

Genetic etiologies of at least 20% of autosomal dominant cerebellar ataxias (ADCAs) have
yet to be clarified. We identified a novel spinocerebellar ataxia (SCA) form in four Japanese …

The number and morphology of mitochondria within a cell are precisely regulated by the
mitochondrial fission and fusion machinery. The human protein, hFis1, participates in …

We report that a fatty acyl transferase, endophilin B1, is required for maintenance of
mitochondrial morphology. Down-regulation of this protein or overexpression of endophilin B1 …

Fis1 in yeast localizes to the outer mitochondrial membrane and facilitates mitochondrial
fission by forming protein complexes with Dnm1 and Mdv1. Fis1 orthologs exist in higher …

Bcl‐x L is a potent inhibitor of apoptosis. While Bcl‐x L can be bound to mitochondria, a
substantial fraction, depending on the cell type or tissue, is found in the cytosol of healthy cells. …

Glucocorticoids (GCs), which play an important role in the normal regulation of bone
remodeling, are widely used as anti-inflammatory and chemotherapeutic agents. However, …