User profiles for Sunny Wong
 | Sunny H. WongLee Kong Chian School of Medicine Verified email at ntu.edu.sg Cited by 20040 |
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …
Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis
SY Wong, AD Seol, PL So, AN Ermilov… - Nature medicine, 2009 - nature.com
Primary cilia are present on most mammalian cells and are implicated in transducing
Hedgehog (Hh) signals during development; however, the prevalence of cilia on human tumors …
Hedgehog (Hh) signals during development; however, the prevalence of cilia on human tumors …
Gut mucosal microbiome across stages of colorectal carcinogenesis
Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we
catalogue the microbial communities in human gut mucosae at different stages of colorectal …
catalogue the microbial communities in human gut mucosae at different stages of colorectal …
Global epidemiology and genetics of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC
develops in genetically susceptible individuals who are exposed to risk factors, especially in …
develops in genetically susceptible individuals who are exposed to risk factors, especially in …
Related searches
Covid‐19 and the digestive system
The novel coronavirus disease is currently causing a major pandemic. It is caused by the
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a member of the …
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a member of the …
Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
Objective To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal
metagenomes. Design We performed metagenome-wide association studies on faecal samples …
metagenomes. Design We performed metagenome-wide association studies on faecal samples …
Updated epidemiology of gastrointestinal cancers in East Asia
Globally, gastrointestinal cancers represent more than one-fourth of all cancer incidence and
one-third of cancer-related mortality. Although there has been much progress in screening …
one-third of cancer-related mortality. Although there has been much progress in screening …
Mucosal microbiome dysbiosis in gastric carcinogenesis
Objectives We aimed to characterise the microbial changes associated with histological
stages of gastric tumourigenesis. Design We performed 16S rRNA gene analysis of gastric …
stages of gastric tumourigenesis. Design We performed 16S rRNA gene analysis of gastric …
[HTML][HTML] Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice
Background & Aims Altered gut microbiota is implicated in development of colorectal cancer
(CRC). Some intestinal bacteria have been reported to potentiate intestinal carcinogenesis …
(CRC). Some intestinal bacteria have been reported to potentiate intestinal carcinogenesis …
[HTML][HTML] Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches
…, CK Bichakjian, NL Ward, AA Dlugosz, SY Wong - Cell stem cell, 2015 - cell.com
Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive
activation of the Hedgehog pathway. Although the requirement for Hedgehog in BCC is …
activation of the Hedgehog pathway. Although the requirement for Hedgehog in BCC is …