The CRISPR/Cas9 system enables genome editing and somatic cell genetic screens in
mammalian cells. We performed genome-scale loss-of-function screens in 33 cancer cell lines to …

Quantitative study of protein-protein and protein-ligand interactions in solution requires
accurate determination of protein concentration. Often, for proteins available only in “molecular …

These findings reveal a differential dependency of clear cell ovarian cancers on EGLN1,
thus identifying EGLN1 as a potential therapeutic target in clear cell ovarian cancer patients. …

Background: Gilteritinib (GIL), a FLT3 inhibitor, shows efficacy/safety in patients (pts) with
FLT3 mut+ relapsed/refractory (R/R) AML. For pts with newly diagnosed (ND) AML with FLT3 …

Most human epithelial tumors harbor numerous alterations, making it difficult to predict which
genes are required for tumor survival. To systematically identify cancer dependencies, we …

Publisher Summary This chapter focuses on the stability of protein structure and hydrophobic
interaction. The interest in hydrophobic interactions was stimulated by their unusual …

Species of RNA that bind with high affinity and specificity to the bronchodilator theophylline
were identified by selection from an oligonucleotide library. One RNA molecule binds to …

By “parallel programming” is meant the control of two or more operations which are executed
virtually simultaneously, and each of which entails following a series of instructions. This …

Ligand-macromolecule interactions are of fundamental importance in the control of biological
processes. This book applies the principles of linkage thermodynamics to polyfunctional …

Protein unfolding and the dissolution of hydrophobic compounds (including solids, liquids,
and gases) in water are characterized by a linear relation between entropy change and heat …