User profiles for Ryan Holland

Ryan J Holland

Food and Drug Administration
Verified email at fda.hhs.gov
Cited by 823

Project sidewalk: A web-based crowdsourcing tool for collecting sidewalk accessibility data at scale

…, M Saugstad, HT Maddali, A Zeng, R Holland… - Proceedings of the …, 2019 - dl.acm.org
We introduce Project Sidewalk, a new web-based tool that enables online crowdworkers to
remotely label pedestrian-related accessibility problems by virtually walking through city …

Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1

R Holland, JC Fishbein - Antioxidants & redox signaling, 2010 - liebertpub.com
The protein Kelch-like ECH-associated protein 1 (Keap1) is a cysteine-rich regulatory and
scaffold protein. Human Keap1 contains 27 cysteines. Some of these cysteines are believed …

Neurologic syndromes predict higher in-hospital mortality in COVID-19

…, D Flomenbaum, J Fernandez-Torres, J Lu, R Holland… - Neurology, 2021 - neurology.org
Objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is protean in its
manifestations, affecting nearly every organ system. However, nervous system involvement …

Prospective type 1 and type 2 disulfides of Keap1 protein

R Holland, AE Hawkins, AL Eggler… - Chemical research in …, 2008 - ACS Publications
Experiments were carried out to detect cysteine residues on human Keap1 protein that may
be sensors of oxidative stress that gives rise to changes in the GSH/GSSG redox couple. …

Hemorrhagic presentations of COVID-19: risk factors for mortality

…, RLG Ramos, R Zampolin, J Benton, R Holland… - Clinical neurology and …, 2020 - Elsevier
Objective We aim to characterize the incidence, risk for mortality, and identify risk factors for
mortality in patients presenting with hemorrhage and COVID-19. Methods This retrospective …

Synthesis and chemical and biological comparison of nitroxyl-and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives

…, S Jain, S Shi, JL Heinecke, RJ Holland… - Journal of medicinal …, 2013 - ACS Publications
Structural modifications of nonsteroidal anti-inflammatory drugs (NSAIDs) have successfully
reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory …

The nitric oxide prodrug JS-K is effective against non–small-cell lung Cancer cells in vitro and in vivo: involvement of reactive oxygen species

…, JE Saavedra, NL Morris, RJ Holland… - The Journal of …, 2011 - Elsevier
Non–small-cell lung cancer is among the most common and deadly forms of human
malignancies. Early detection is unusual, and there are no curative therapies in most cases. …

Managing a specialty service during the COVID-19 crisis: lessons from a New York City health system

A Ammar, AD Stock, R Holland, Y Gelfand… - Academic …, 2020 - journals.lww.com
The COVID-19 pandemic has stretched health care resources to a point of crisis throughout
the world. To answer the call for care, health care workers in a diverse range of specialties …

[HTML][HTML] Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance

AE Maciag, RJ Holland, YSR Cheng, LG Rodriguez… - Redox biology, 2013 - Elsevier
JS-K is a nitric oxide (NO)-releasing prodrug of the O 2 -arylated diazeniumdiolate family that
has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer …

[HTML][HTML] Biomarkers of coagulation and inflammation in COVID-19–associated ischemic stroke

…, J Seiden, I Goldman, D Altschul, R Holland… - 2021 - journals.lww.com
Background and Purpose: We sought to determine if biomarkers of inflammation and coagulation
can help define coronavirus disease 2019 (COVID-19)–associated ischemic stroke as …