User profiles for Ryan Holland
Ryan J HollandFood and Drug Administration Verified email at fda.hhs.gov Cited by 823 |
Project sidewalk: A web-based crowdsourcing tool for collecting sidewalk accessibility data at scale
…, M Saugstad, HT Maddali, A Zeng, R Holland… - Proceedings of the …, 2019 - dl.acm.org
We introduce Project Sidewalk, a new web-based tool that enables online crowdworkers to
remotely label pedestrian-related accessibility problems by virtually walking through city …
remotely label pedestrian-related accessibility problems by virtually walking through city …
Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1
R Holland, JC Fishbein - Antioxidants & redox signaling, 2010 - liebertpub.com
The protein Kelch-like ECH-associated protein 1 (Keap1) is a cysteine-rich regulatory and
scaffold protein. Human Keap1 contains 27 cysteines. Some of these cysteines are believed …
scaffold protein. Human Keap1 contains 27 cysteines. Some of these cysteines are believed …
Neurologic syndromes predict higher in-hospital mortality in COVID-19
…, D Flomenbaum, J Fernandez-Torres, J Lu, R Holland… - Neurology, 2021 - neurology.org
Objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is protean in its
manifestations, affecting nearly every organ system. However, nervous system involvement …
manifestations, affecting nearly every organ system. However, nervous system involvement …
Prospective type 1 and type 2 disulfides of Keap1 protein
Experiments were carried out to detect cysteine residues on human Keap1 protein that may
be sensors of oxidative stress that gives rise to changes in the GSH/GSSG redox couple. …
be sensors of oxidative stress that gives rise to changes in the GSH/GSSG redox couple. …
Hemorrhagic presentations of COVID-19: risk factors for mortality
…, RLG Ramos, R Zampolin, J Benton, R Holland… - Clinical neurology and …, 2020 - Elsevier
Objective We aim to characterize the incidence, risk for mortality, and identify risk factors for
mortality in patients presenting with hemorrhage and COVID-19. Methods This retrospective …
mortality in patients presenting with hemorrhage and COVID-19. Methods This retrospective …
Synthesis and chemical and biological comparison of nitroxyl-and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives
…, S Jain, S Shi, JL Heinecke, RJ Holland… - Journal of medicinal …, 2013 - ACS Publications
Structural modifications of nonsteroidal anti-inflammatory drugs (NSAIDs) have successfully
reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory …
reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory …
The nitric oxide prodrug JS-K is effective against non–small-cell lung Cancer cells in vitro and in vivo: involvement of reactive oxygen species
…, JE Saavedra, NL Morris, RJ Holland… - The Journal of …, 2011 - Elsevier
Non–small-cell lung cancer is among the most common and deadly forms of human
malignancies. Early detection is unusual, and there are no curative therapies in most cases. …
malignancies. Early detection is unusual, and there are no curative therapies in most cases. …
Managing a specialty service during the COVID-19 crisis: lessons from a New York City health system
A Ammar, AD Stock, R Holland, Y Gelfand… - Academic …, 2020 - journals.lww.com
The COVID-19 pandemic has stretched health care resources to a point of crisis throughout
the world. To answer the call for care, health care workers in a diverse range of specialties …
the world. To answer the call for care, health care workers in a diverse range of specialties …
[HTML][HTML] Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance
AE Maciag, RJ Holland, YSR Cheng, LG Rodriguez… - Redox biology, 2013 - Elsevier
JS-K is a nitric oxide (NO)-releasing prodrug of the O 2 -arylated diazeniumdiolate family that
has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer …
has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer …
[HTML][HTML] Biomarkers of coagulation and inflammation in COVID-19–associated ischemic stroke
…, J Seiden, I Goldman, D Altschul, R Holland… - 2021 - journals.lww.com
Background and Purpose: We sought to determine if biomarkers of inflammation and coagulation
can help define coronavirus disease 2019 (COVID-19)–associated ischemic stroke as …
can help define coronavirus disease 2019 (COVID-19)–associated ischemic stroke as …