Structures of influenza A proteins and insights into antiviral drug targets

K Das, JM Aramini, LC Ma, RM Krug… - Nature structural & …, 2010 - nature.com
The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-called
'swine flu'. The H5N1 ('bird flu') influenza A viruses, now circulating in Asia, Africa and …

[HTML][HTML] Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein

RM Krug, W Yuan, DL Noah, AG Latham - Virology, 2003 - Elsevier
Virus-infected mammalian cells are a battleground: cells mount antiviral defenses against
the virus, and these defenses are countered by the infecting virus. The eventual outcome of …

High-resolution imaging techniques for the assessment of osteoporosis

R Krug, AJ Burghardt, S Majumdar… - Radiologic Clinics of …, 2010 - pmc.ncbi.nlm.nih.gov
Krug) further maximized the contrast between the dark cortical bone and the relatively dark
… b) Double-oblique MR image (right) of the femoral neck acquired by R. Krug at 3 Tesla …

Enthalpy-entropy compensation. 2. Separation of the chemical from the statistical effect

RR Krug, WG Hunter, RA Grieger - The Journal of Physical …, 1976 - ACS Publications
For problems concerning enthalpy-entropy compensations, an appropriate regression
procedure is present-ed for the estimation of functional dependencies between thermodynamic …

Statistical interpretation of enthalpy–entropy compensation

RR Krug, WG Hunter, RA Grieger - Nature, 1976 - nature.com
TYPICALLY, enthalpy and entropy estimates from kinetic and equilibrium data are highly
correlated, varying in a linear fashion with one another (enthalpy–entropy compensation effect). …

Enthalpy-entropy compensation. 1. Some fundamental statistical problems associated with the analysis of van't Hoff and Arrhenius data

RR Krug, WG Hunter, RA Grieger - The Journal of Physical …, 1976 - ACS Publications
… variations inAH and AS are small compared to the uncertainty of theestimates of these parameters,
the experiments are essentially replications and the estimated correlation coefficient r

A unique cap (m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription

SJ Plotch, M Bouloy, I Ulmanen, RM Krug - Cell, 1981 - cell.com
We propose a mechanism for the priming of influenza viral RNA transcription by capped
RNAs in which specific Y-terminal fragments are cleaved from the capped RNAs by a virion-…

Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′ end formation of cellular pre-mRNAs

ME Nemeroff, SML Barabino, Y Li, W Keller, RM Krug - Molecular cell, 1998 - cell.com
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus
NS1 protein requires its effector domain. Here, we demonstrate that the NS1 effector …

[HTML][HTML] Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)‐induced ubiquitin‐like ISG15 protein

W Yuan, RM Krug - The EMBO journal, 2001 - embopress.org
Of the several hundred proteins induced by interferon (IFN) α/β, the ubiquitin‐like ISG15
protein is one of the most predominant. We demonstrate the novel way in which the function of …

The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2′-5′ oligo (A) synthetase/RNase L pathway

JY Min, RM Krug - Proceedings of the National Academy of Sciences, 2006 - pnas.org
… The only amino acid absolutely required for dsRNA binding is the R at position 38. To
identify the role of this dsRNA-binding activity during influenza A virus infection, we generated a …