OBJECTIVE: Three-dimensional (3D) cultures are widely used to redifferentiate chondrocytes.
However, the rationale behind the choice for 3D above two-dimensional (2D) cultures is …

These animal data, together with the view of limited scientifically robust clinical evidence in
humans, indicate that physicians consider only short-term administration of COX-2 inhibitors …

Treatment of full-thickness damage to hyaline cartilage is hampered by the limited
availability of autologous healthy cartilage and the lengthy, cost-prohibitive cell isolation and …

Background GPs have high consultation rates for symptoms related to knee osteoarthritis (OA).
Many risk factors for symptomatic knee OA progression remain unknown. Aim To define …

… van Rhijn contributed to section 1 and 4 and shared his long-standing expertise as orthopedic
surgeon; Pieter J. Emans greatly contributed to all sections of this review and shared his …

In this study, we investigated the potential of celecoxib-loaded polyester amide (PEA)
microspheres as an auto-regulating drug delivery system for the treatment of pain associated with …

Objective Early and non-invasive detection of osteoarthritis (OA) is required to enable early
treatment and monitoring of interventions. Some of the earliest signs of OA are the change in …

… Author links open overlay panel Pieter J. Emans a , Frank Spaapen c , Don AM Surtel a , …
VEGF expression is up-regulated 20 days post-surgery (J). Quantitative RT-PCR expression …

Background We aimed to evaluate the prevalence of hip and knee osteoarthritis (HOA and
KOA) according to American College of Rheumatology (ACR) criteria among participants with …

Background NF-κB/p65 has been reported to be involved in regulation of chondrogenic
differentiation. However, its function in relation to key chondrogenic factor Sox9 and onset of …