Background Psychotic disorders, such as schizophrenia, are associated with neuroanatomical
abnormalities, but whether these predate the onset of symptoms or develop progressively …

Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Watching a speaker’s lips during face-to-face conversation (lipreading) markedly improves
speech perception, particularly in noisy conditions. With functional magnetic resonance …

The neural correlates of verbal self-monitoring were examined by measuring the response to
alterations in auditory verbal feedback while subjects read aloud. Six normal subjects were …

Background Schizophrenia is characterized by small reductions in cortical gray matter
volume, particularly in the temporal and prefrontal cortices. The question of whether cortical …

Context A major limitation on the development of biomarkers and novel interventions for
schizophrenia is that its pathogenesis is unknown. Although elevated striatal dopamine activity …

Δ-9-tetrahydrocannabinol (Δ-9-THC) and Cannabidiol (CBD), the two main ingredients of the
Cannabis sativa plant have distinct symptomatic and behavioral effects. We used functional …

Background Perceptions of speech in the absence of an auditory stimulus (auditory verbal
hallucinations) are a cardinal feature of schizophrenia. Functional neuroimaging provides a …

Background: The current diagnostic system for subjects at enhanced clinical risk of psychosis
allows concurrent comorbid diagnoses of anxiety and depressive disorders. Their impact …

Animal and human studies indicate that cannabidiol (CBD), a major constituent of cannabis,
has anxiolytic properties. However, no study to date has investigated the effects of this …