The gut microbiota has recently been identified as an environmental factor that may promote
metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid …

Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of
many cancers. However, the precise molecular composition of lipids in tumors remains …

The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms
regulating progress toward β cell failure, and factors determining time of presentation of clinical …

Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated
isoform of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2 −/− Lep ob /Lep …

Background Success of metabolomics as the phenotyping platform largely depends on its
ability to detect various sources of biological variability. Removal of platform-specific sources …

OBJECTIVE— We sought to determine whether adipose tissue is inflamed in individuals with
increased liver fat (LFAT) independently of obesity. RESEARCH DESIGN AND METHODS…

Aims Genetics plays an important role in coronary heart disease (CHD) but the clinical utility
of genomic risk scores (GRSs) relative to clinical risk scores, such as the Framingham Risk …

Background Lipids are an important and highly diverse class of molecules having structural,
energy storage and signaling roles. Modern analytical technologies afford screening of …

Identification of early mechanisms that may lead from obesity towards complications such as
metabolic syndrome is of great interest. Here we performed lipidomic analyses of adipose …

Recent advances in mass spectrometry (MS)-based techniques for lipidomic analysis have
empowered us with the tools that afford studies of lipidomes at the systems level. However, …