We propose a novel approach for loss reserving based on deep neural networks. The
approach allows for joint modeling of paid losses and claims outstanding, and incorporation of …

Background Patients with transfusion-dependent β-thalassemia need regular red-cell
transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth …

Stroke, characterized as a neurological deficit of cerebrovascular cause, is very common in
older adults. Increasing evidence suggests stroke contributes to the risk and severity of …

Background Pyruvate kinase deficiency is caused by mutations in PKLR and leads to
congenital hemolytic anemia. Mitapivat is an oral, small-molecule allosteric activator of pyruvate …

In 2011, Lake Erie experienced the largest harmful algal bloom in its recorded history, with a
peak intensity over three times greater than any previously observed bloom. Here we show …

Background Patients with non-transfusion-dependent thalassaemia (NTDT), although they
do not require regular blood transfusions for survival, can still accrue a heavy burden of …

An international, multicenter registry was established to collect retrospective and prospective
clinical data on patients with pyruvate kinase (PK) deficiency, the most common glycolytic …

Previous hypothesis-driven research has identified many risk factors linked to dementia.
However, the multiplicity and co-occurrence of risk factors have been underestimated. Here we …

Lifestyle factors have been acknowledged to be modifiable targets that can be used to
counter the increasing prevalence of depression. This study aims to investigate combining an …

Pregnancy in women with sickle cell disease is associated with adverse maternal and
neonatal outcomes. Studies assessing the effects of prophylactic red blood cell transfusions on …