Shortly after implantation the mouse embryo comprises three tissue layers. The founder
tissue of the embryo proper, the epiblast, forms a radially symmetric cup of epithelial cells that …

Wnt genes comprise a large family of secreted polypeptides that are expressed in spatially
and tissue-restricted patterns during vertebrate embryonic development 1 . Mutational …

We describe the successful application of a modified gene-trap approach, the secretory trap,
to systematically analyze the functions in vivo of large numbers of genes encoding secreted …

Nodal is expressed at the lateral edges of the mouse node, but its function in this “organizer”
tissue remains unknown due to the early lethality of Nodal mutant embryos. Here we used a …

Although much remains unknown about how the embryonic axis is laid down in the mouse,
it is now clear that reciprocal interactions between the extraembryonic and embryonic …

The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is an international
consortium working to generate gene expression data and transgenic mice. GUDMAP …

The TGFβ-related growth factor Nodal governs anteroposterior (AP) and left-right (LR) axis
formation in the vertebrate embryo. A conserved intronic enhancer (ASE), containing binding …

Malformation of the urogenital tract represents a considerable paediatric burden, with many
defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. …

Cataloguing gene expression during development of the genitourinary tract will increase our
understanding not only of this process but also of congenital defects and disease affecting …

The human immune response to bovine dermal collagen was characterized through histologic,
serologic, and immunoblotting methods. Collagen-sensitive patients were identified by …