Quantitative structure–property/activity relationships (QSPRs/QSARs) are a tool (in silico) to
rapidly predict various endpoints in general, and drug toxicity in particular. However, this …

Acetylcholinesterase (AChE) inhibitors, dihydrofolate reductase inhibitors (DHFR), Toxicity
in Tetrahymena pyriformis (TP), Acute Toxicity in fathead minnow (TFat), Water solubility (WS)…

Nuclear retinoic acid (RA) receptors (RARs) activate gene expression through dynamic
interactions with coregulators in coordination with the ligand and phosphorylation processes. …

The peptidyl-prolyl-isomerase Pin1 interacts with phosphorylated proteins, altering their
conformation. The retinoic acid receptor RARα and the acute-promyelocytic-leukemia–specific …

Background We hypothesized that with the administration of teriparatide (TPTD) treatment
at different times, we would be able to modify the physiological circadian rhythm of bone …

Hypocalcaemic cardiomyopathy is a rare form of dilated cardiomyopathy. The authors here
present two cases in which symptomatic dilated cardiomyopathy was the result of severe …

Background: Bone marrow stromal cells (BMSCs) are the source of multipotent stem cells,
which are important for regenerative medicine and diagnostic purposes. The isolation of …

Quantitative structure - activity relationships (QSARs) for the pIC50 (binding affinity) of
gamma-secretase inhibitors can be constructed with the Monte Carlo method using CORAL …

By means of immunocytochemistry performed on cryosections of cultured cells, RNA
polymerase I was localized mainly to nucleolae fibrillar centers. The labelling of nucleolar dense …

The retinoid-related molecules (RRMs) ST1926 [(E)-3-(4′-hydroxy-3′-adamantylbiphenyl-4-yl)acrylic
acid] and CD437 (6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene …