Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting
role is highly context dependent. Oncogenic Kras mutation is the signature event in …

The TCL1 gene at 14q32.1 is involved in chromosomal translocations and inversions in
mature T cell leukemias. These leukemias are classified either as T prolymphocytic leukemias, …

The assessment of regional climate change requires the development of reference long-term
retrospective meteorological datasets. This article presents an 8-km-resolution atmospheric …

A new high-resolution regional climate change ensemble has been established for Europe
within the World Climate Research Program Coordinated Regional Downscaling Experiment …

Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and apoptosis
to drive progressive atrophy and functional decline in high-turnover tissues. The broader …

Tumorigenesis is a multistep process characterized by a myriad of genetic and epigenetic
alterations. Identifying the causal perturbations that confer malignant transformation is a …

Screening a diverse, combinatorial library of ca. 5000 synthetic dimer and trimer N-(substituted)
glycine “peptoids” yielded novel, high-affinity ligands for 7-transmembrane G-protein-…

Système d’analyse fournissant des renseignements atmosphériques à la neige (SAFRAN)
is a mesoscale atmospheric analysis system for surface variables. It produces an analysis at …

Highly rearranged and mutated cancer genomes present major challenges in the
identification of pathogenetic events driving the neoplastic transformation process. Here we …

SURFEX is a new externalized land and ocean surface platform that describes the surface
fluxes and the evolution of four types of surfaces: nature, town, inland water and ocean. It is …