User profiles for Douwe Van Sinderen

Douwe Van Sinderen

Professor of Molecular Microbiology, School of Microbiology & APC Microbiome Ireland …
Verified email at ucc.ie
Cited by 60526

Identification and characterization of phage‐resistance genes in temperate lactococcal bacteriophages

S McGrath, GF Fitzgerald, D Sinderen - Molecular microbiology, 2002 - Wiley Online Library
The sie 2009 gene, which is situated between the genes encoding the repressor and
integrase, on the lysogeny module of the temperate lactococcal bacteriophage Tuc2009, was …

Gut microbiota composition correlates with diet and health in the elderly

…, N Harnedy, K O'connor, D O'mahony, D Van Sinderen… - Nature, 2012 - nature.com
Alterations in intestinal microbiota composition are associated with several chronic conditions,
including obesity and inflammatory diseases. The microbiota of older people displays …

The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

…, A Margolles, D Van Sinderen… - Microbiology and …, 2017 - journals.asm.org
The human gut microbiota is engaged in multiple interactions affecting host health during the
host's entire life span. Microbes colonize the neonatal gut immediately following birth. The …

[HTML][HTML] Shaping the future of probiotics and prebiotics

…, RE Steinert, KS Swanson, D van Sinderen… - Trends in …, 2021 - cell.com
Recent and ongoing developments in microbiome science are enabling new frontiers of
research for probiotics and prebiotics. Novel types, mechanisms, and applications currently …

Functional and structural dissection of the tape measure protein of lactococcal phage TP901-1

…, S Spinelli, M Feyereisen, C Cambillau, D Sinderen - Scientific reports, 2016 - nature.com
The tail tape measure protein (TMP) of tailed bacteriophages (also called phages) dictates
the tail length and facilitates DNA transit to the cell cytoplasm during infection. Here, a …

Lactococcal 936-type phages and dairy fermentation problems: from detection to evolution and prevention

J Mahony, J Murphy, D Sinderen - Frontiers in microbiology, 2012 - frontiersin.org
The so-called 936-type phages are the most frequently encountered lactococcal phage
species in dairy fermentations, where they cause slow or even failed fermentations with …

[HTML][HTML] The application of metagenomics to study microbial communities and develop desirable traits in fermented foods

M Srinivas, O O'Sullivan, PD Cotter, D Sinderen… - Foods, 2022 - mdpi.com
The microbial communities present within fermented foods are diverse and dynamic,
producing a variety of metabolites responsible for the fermentation processes, imparting …

Comparative genomics of the Bifidobacterium brevetaxon

…, A Zomer, D Zhurina, C Riedel, M Ventura, D Sinderen - BMC genomics, 2014 - Springer
Background Bifidobacteria are commonly found as part of the microbiota of the gastrointestinal
tract (GIT) of a broad range of hosts, where their presence is positively correlated with the …

Assessing the fecal microbiota: an optimized ion torrent 16S rRNA gene-based analysis protocol

…, B Sanchez, R Martin, M Gueimonde, D van Sinderen… - PloS one, 2013 - journals.plos.org
Assessing the distribution of 16S rRNA gene sequences within a biological sample
represents the current state-of-the-art for determination of human gut microbiota composition. …

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

…, G Fitzgerald, C Stanton, D van Sinderen… - Proceedings of the …, 2011 - pnas.org
Alterations in the human intestinal microbiota are linked to conditions including inflammatory
bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes …