Type 2 diabetes is a disorder of hyperglycemia resulting from failure of beta cells to produce
adequate insulin to accommodate an increased metabolic demand. Here we show that …

Free fatty acids cause pancreatic β-cell apoptosis and may contribute to β-cell loss in type 2
diabetes via the induction of endoplasmic reticulum stress. Reductions in eukaryotic …

Rat pancreatic α- and β-cells are critically dependent on hormonal signals generating cyclic
AMP (cAMP) as a synergistic messenger for nutrient-induced hormone release. Several …

AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism.
To understand better the physiological role of the catalytic AMPK subunit isoforms, we …

OBJECTIVE Cytokines contribute to pancreatic β-cell death in type 1 diabetes. This effect is
mediated by complex gene networks that remain to be characterized. We presently utilized …

Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ
hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed …

Incretins are gastrointestinal hormones that act on the pancreas to potentiate glucose-stimulated
insulin secretion. Despite the physiological importance of the enteroinsular axis, …

Background Gene expression patterns provide a detailed view of cellular functions.
Comparison of profiles in disease vs normal conditions provides insights into the processes …

Aims/hypothesis The secretory function of pancreatic beta cells is synergistically stimulated
by two signalling pathways which mediate the effects of nutrients and hormones such as …

OBJECTIVE— Viral infections contribute to the pathogenesis of type 1 diabetes. Viruses, or
viral products such as double-stranded RNA (dsRNA), affect pancreatic β-cell survival and …