Dynamic generative model of the human brain in resting-state

D Guo, V Arora, E Amico, J Goñi… - Complex Networks & Their …, 2018 - Springer
Complex Networks & Their Applications VI: Proceedings of Complex Networks 2017 …, 2018Springer
The human connectome is constructed by translating neuron activities into a complex
network with nodes and edges. Although the topology of such networks is well studied, the
formation rules and dynamics are not fully understood. It is challenging to develop a
generative model for large scale dynamic complex networks due to the computational
obstacle and nontrivial network structure. To study the node-based and subject-based
network dynamics in resting-state brain, we divide the brain scan session into several sliding …
Abstract
The human connectome is constructed by translating neuron activities into a complex network with nodes and edges. Although the topology of such networks is well studied, the formation rules and dynamics are not fully understood. It is challenging to develop a generative model for large scale dynamic complex networks due to the computational obstacle and nontrivial network structure. To study the node-based and subject-based network dynamics in resting-state brain, we divide the brain scan session into several sliding windows and generate a network for each segment. Then, an action-based model generator, which generates edges according to a topology manipulating actions, is fitted to the network series. This model, presumably as the first applicable approach for synthesizing the brain network dynamics, is shown capable of synthesizing a network series of the action-based model. Also, the estimated parameters shows that the actions of brain regions are related to their functionality.
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