Multi-label feature selection, which is an efficient and effective pre-processing step in machine learning and data mining, can select a feature subset that contains more contributions for multi-label classification while improving the performance of the classifiers. In real-world applications, an instance may be associated with multiple related labels with different relative importances, and the process of obtaining different features usually requires different costs, containing money, and time, etc. However, most existing works with regard to multi-label feature selection do not take into consideration the above two critical issues simultaneously. Therefore, in this paper, we exploit the idea of neighborhood granularity to enhance the traditional logical labels into label distribution forms to excavate the deeper supervised information hidden in multi-label data, and further consider the effect of the test cost under three different distributions, simultaneously. Motivated by these issues, a novel test cost multi-label feature selection algorithm with label enhancement and neighborhood granularity is designed. Moreover, the proposed algorithm is tested upon ten publicly available benchmark multi-label datasets with six widely-used metrics from two different aspects. Finally, two groups of experimental results demonstrate that the proposed algorithm achieves the satisfactory and superior performance over other four state-of-the-art comparing algorithms, and it is effective for improving the learning performance and decreasing the total test costs of the selected feature subset.