User profiles for Angel Yu

Angel Yu

MIT
Verified email at alum.mit.edu
Cited by 36

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system

…, M Vuckovic, RA Pfuetzner, W Deng, AC Yu… - Nature structural & …, 2009 - nature.com
The type III secretion system (T3SS) is a macromolecular 'injectisome' that allows bacterial
pathogens to transport virulence proteins into the eukaryotic host cell. This macromolecular …

The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer

YJ Chern, JCT Wong, GSW Cheng, A Yu, Y Yin… - Cell death & …, 2019 - nature.com
Therapy-refractory disease is one of the main contributors of treatment failure in cancer. In
colorectal cancer (CRC), SPARC can function as a sensitizer to conventional chemotherapy …

A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly

…, RA Pfuetzner, HB Felise, M Vuckovic, AC Yu… - PLoS …, 2013 - journals.plos.org
The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic
Gram-negative bacteria that allows for the direct delivery of virulence effectors into host cells. …

Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53‐mediated cellular senescence

…, MR Hasan, M Rahman, AC Yu… - … journal of cancer, 2013 - Wiley Online Library
Dysregulation of nucleophosmin 1 (NPM1) has been found in numerous solid and hematological
malignancies. Our previous meta‐analysis of colorectal cancer (CRC) high throughput …

Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient-derived xenografts via activation of p53 and inhibition of AKT

ACY Yu, YJ Chern, P Zhang, CC Pasiliao… - Cancer Biology & …, 2021 - Taylor & Francis
The nucleophosmin 1 (NPM1) protein is frequently overexpressed in various cancers
compared to normal tissues and represents a potential biomarker for maliganancy. However, its …

Crystal structure of the Propionibacterium acnes surface sialidase, a drug target for P. acnes-associated diseases

ACY Yu, G Volkers, SAK Jongkees, LJ Worrall… - …, 2022 - academic.oup.com
Propionibacterium acnes, though generally considered part of the normal flora of human
skin, is an opportunistic pathogen associated with acne vulgaris as well as other diseases, …

Distributed MCMC inference in Dirichlet process mixture models using Julia

O Dinari, A Yu, O Freifeld… - 2019 19th IEEE/ACM …, 2019 - ieeexplore.ieee.org
Due to the increasing availability of large data sets, the need for general-purpose massively-parallel
analysis tools become ever greater. In unsupervised learning, Bayesian …

Rediscovered Voices: Chinese Immigrants and Angel Island

CY Yu - Amerasia Journal, 1977 - Taylor & Francis
The Cantonese immigrant stood on the bench by the grated window and carefully carved out
the words he had first written with a brush. Other immigrants, frustrated by long detention in …

EscE and EscG are cochaperones for the type III needle protein EscF of enteropathogenic Escherichia coli

…, D Setiaputra, R Scholz, W Deng, ACY Yu… - Journal of …, 2013 - journals.asm.org
Type III secretion systems (T3SSs) are central virulence mechanisms used by a variety of
Gram-negative bacteria to inject effector proteins into host cells. The needle polymer is an …

[PDF][PDF] Angel: a new large-scale machine learning system

J Jiang, L Yu, J Jiang, Y Liu, B Cui - National Science Review, 2018 - academic.oup.com
… , we introduce the modules of Angel, and how Angel executes ML applications. … Angel by
comparing Angel with Spark and Petuum using various ML algorithms. We also compare Angel