Since the discovery in the 1980s that nitric oxide (NO) is in fact the elusive endothelium-derived
relaxing factor, it has become evident that NO is not only a major cardiovascular …

Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …

Background—Previous studies from our laboratory showed cyclic increases in tissue cAMP
during a multiple-cycle preconditioning (PC) protocol, followed by attenuated cAMP …

Methods In the studies designed to compare the effects of, 3-hy-droxybutyrate and acetoacetate
on the arterialglucose concentration of totally diabetic depancreatized and partially …

Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative
stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and …

Since it was identified as the elusive endothelium-derived relaxing factor (EDRF) in the
1980s, nitric oxide (NO) has rapidly gained status as one of the most important signalling …

The metabolic syndrome ( M et S ) is a cluster of metabolic abnormalities associated with
increased risk for cardiovascular diseases. Apart from its powerful antioxidant properties, the …

Melatonin is a pleiotropic hormone with several functions. It binds to specific receptors and to
a number of cytosolic proteins, activating a vast array of signalling pathways. Its potential to …

Cardiovascular risk is closely associated with insulin resistance and type 2 diabetes. Therapy
based on the actions of GLP-1 is currently seen as a novel approach to treat this disease. …

Melatonin has potent cardioprotective properties. These actions have been attributed to its
free radical scavenging and anti‐oxidant actions, but may also be receptor mediated. …