Myosin V is a dimeric molecular motor that moves processively on actin, with the center of
mass moving ∼37 nanometers for each adenosine triphosphate hydrolyzed. We have labeled …

Kinesin is a processive motor that takes 8.3-nm center-of-mass steps along microtubules for
each adenosine triphosphate hydrolyzed. Whether kinesin moves by a “hand-over-hand” or …

The RNA-guided CRISPR–Cas9 nuclease from Streptococcus pyogenes (SpCas9) has
been widely repurposed for genome editing 1 , 2 , 3 , 4 . High-fidelity (SpCas9-HF1) and …

We introduce the technique of FIONA, fluorescence imaging with one nanometer accuracy.
This is a fluorescence technique that is able to localize the position of a single dye within ∼1 …

Cytoplasmic dynein, the 1.2 MDa motor driving minus-end-directed motility, has been reported
to move processively along microtubules, but its mechanism of motility remains poorly …

Kinesin advances 8 nm along a microtubule per ATP hydrolyzed, but the mechanism responsible
for coordinating the enzymatic cycles of kinesin's two identical motor domains remains …

Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence
of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to …

The Cas9 endonuclease is widely used for genome engineering applications by programming
its single-guide RNA, and ongoing work is aimed at improving the accuracy and efficiency …

Highly infectious illness caused by pathogens is endemic especially in developing nations
where there is limited laboratory infrastructure and trained personnel. Rapid point-of-care (…

Background Coronary artery anomalies are found in 0.2% to 1.3% of patients undergoing
coronary angiography and 0.3% of an autopsy series. We aimed to estimate the frequency of …