The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest
challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the annual …

Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia
and now poses a threat to the control and elimination of malaria. Mapping the geographic …

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …

We report a large multicenter genome-wide association study of Plasmodium falciparum
resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, …

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …

Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …

Background Evidence suggests that the PfKelch13 mutations that confer artemisinin
resistance in falciparum malaria have multiple independent origins across the Greater Mekong …

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated with …

Background. The emergence of artemisinin-resistant Plasmodium falciparum in Southeast
Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. …

Background As the prevalence of artemisinin-resistant Plasmodium falciparum malaria
increases in the Greater Mekong subregion, emerging resistance to partner drugs in artemisinin …