Fat-associated lymphoid clusters (FALCs) are a type of lymphoid tissue associated with
visceral fat. Here we found that the distribution of FALCs was heterogeneous, with the …

Alloreactive memory T cells may be refractory to many of the tolerance-inducing strategies
that are effective against naive T cells and thus present a significant barrier to long-term …

Thrombosis is a common, life-threatening consequence of systemic infection; however, the
underlying mechanisms that drive the formation of infection-associated thrombi are poorly …

Although it is widely accepted that there is a hierarchy in the susceptibility of different
allografts to rejection, the mechanisms responsible are unknown. We show that the increased …

Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected
rodent and in primate models, but, due to the ability of CD154-independent CD8+ T cells …

In the thymus, interactions with both cortical and medullary microenvironments regulate the
development of self-tolerant conventional CD4+ and CD8+ αβT cells expressing a wide …

T cells must be activated before they can elicit damage to allografts, through interaction of
their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. …

Accumulating evidence suggests that alloreactive memory T cells (Tm) may be generated in
transplant recipients that have not previously been exposed to alloantigen through …

The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms
that control this multifaceted development are poorly understood. Here we examine …

T helper (Th) type 17 cells are a recently described CD4+ T-cell subset that may contribute
to allograft rejection and act as a barrier to the induction of transplant tolerance. This review …