International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

…, GM Weber, N Gehlenborg, P Avillach, NP Palmer… - NPJ digital …, 2020 - nature.com
We leveraged the largely untapped resource of electronic health record data to address critical
clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To …

A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers

NP Palmer, PR Schmid, B Berger, IS Kohane - Genome biology, 2012 - Springer
Background Understanding the fundamental mechanisms of tumorigenesis remains one of
the most pressing problems in modern biology. To this end, stem-like cells with tumor-…

Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities

S Nazeen, NP Palmer, B Berger, IS Kohane - Genome biology, 2016 - Springer
Background Autism spectrum disorder (ASD) is a common neurodevelopmental disorder
that tends to co-occur with other diseases, including asthma, inflammatory bowel disease, …

SurvMaximin: robust federated approach to transporting survival risk prediction models

…, GA Brat, CL Bonzel, Y Luo, R Duan, NP Palmer… - Journal of biomedical …, 2022 - Elsevier
Objective For multi-center heterogeneous Real-World Data (RWD) with time-to-event outcomes
and high-dimensional features, we propose the SurvMaximin algorithm to estimate Cox …

Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease

NP Palmer, JA Silvester, JJ Lee, AL Beam, I Fried… - PloS one, 2019 - journals.plos.org
Background Presenting features of inflammatory bowel disease (IBD) are non-specific. We
hypothesized that mRNA profiles could (1) identify genes and pathways involved in disease …

International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality

GM Weber, C Hong, Z Xia, NP Palmer, P Avillach… - NPJ digital …, 2022 - nature.com
Given the growing number of prediction algorithms developed to predict COVID-19 mortality,
we evaluated the transportability of a mortality prediction algorithm using a multi-national …

iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls

D Prilutsky, NP Palmer… - Trends in molecular …, 2014 - cell.com
The elucidation of disease etiologies and establishment of robust, scalable, high-throughput
screening assays for autism spectrum disorders (ASDs) have been impeded by both …

Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes

…, NP Palmer, S Churchill, NA Shadick, P Szolovits… - Scientific data, 2019 - nature.com
We develop an algorithm for probabilistic linkage of de-identified research datasets at the
patient level, when only diagnosis codes with discrepancies and no personal health identifiers …

[HTML][HTML] International changes in COVID-19 clinical trajectories across 315 hospitals and 6 countries: retrospective cohort study

…, P Avillach, A Gutierrez-Sacristan, NP Palmer… - Journal of medical …, 2021 - jmir.org
Background Many countries have experienced 2 predominant waves of COVID-19–related
hospitalizations. Comparing the clinical trajectories of patients hospitalized in separate …

Predicting falls in people aged 65 years and older from insurance claims

ML Homer, NP Palmer, KP Fox, J Armstrong… - The American journal of …, 2017 - Elsevier
Background Accidental falls among people aged 65 years and older caused approximately
2,700,000 injuries, 27,000 deaths, and cost more than 34 billion dollars in the US annually in …