International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
We leveraged the largely untapped resource of electronic health record data to address critical
clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To …
clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To …
A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers
Background Understanding the fundamental mechanisms of tumorigenesis remains one of
the most pressing problems in modern biology. To this end, stem-like cells with tumor-…
the most pressing problems in modern biology. To this end, stem-like cells with tumor-…
Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities
Background Autism spectrum disorder (ASD) is a common neurodevelopmental disorder
that tends to co-occur with other diseases, including asthma, inflammatory bowel disease, …
that tends to co-occur with other diseases, including asthma, inflammatory bowel disease, …
SurvMaximin: robust federated approach to transporting survival risk prediction models
Objective For multi-center heterogeneous Real-World Data (RWD) with time-to-event outcomes
and high-dimensional features, we propose the SurvMaximin algorithm to estimate Cox …
and high-dimensional features, we propose the SurvMaximin algorithm to estimate Cox …
Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease
Background Presenting features of inflammatory bowel disease (IBD) are non-specific. We
hypothesized that mRNA profiles could (1) identify genes and pathways involved in disease …
hypothesized that mRNA profiles could (1) identify genes and pathways involved in disease …
International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality
Given the growing number of prediction algorithms developed to predict COVID-19 mortality,
we evaluated the transportability of a mortality prediction algorithm using a multi-national …
we evaluated the transportability of a mortality prediction algorithm using a multi-national …
iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls
D Prilutsky, NP Palmer… - Trends in molecular …, 2014 - cell.com
The elucidation of disease etiologies and establishment of robust, scalable, high-throughput
screening assays for autism spectrum disorders (ASDs) have been impeded by both …
screening assays for autism spectrum disorders (ASDs) have been impeded by both …
Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes
…, NP Palmer, S Churchill, NA Shadick, P Szolovits… - Scientific data, 2019 - nature.com
We develop an algorithm for probabilistic linkage of de-identified research datasets at the
patient level, when only diagnosis codes with discrepancies and no personal health identifiers …
patient level, when only diagnosis codes with discrepancies and no personal health identifiers …
[HTML][HTML] International changes in COVID-19 clinical trajectories across 315 hospitals and 6 countries: retrospective cohort study
…, P Avillach, A Gutierrez-Sacristan, NP Palmer… - Journal of medical …, 2021 - jmir.org
Background Many countries have experienced 2 predominant waves of COVID-19–related
hospitalizations. Comparing the clinical trajectories of patients hospitalized in separate …
hospitalizations. Comparing the clinical trajectories of patients hospitalized in separate …
Predicting falls in people aged 65 years and older from insurance claims
ML Homer, NP Palmer, KP Fox, J Armstrong… - The American journal of …, 2017 - Elsevier
Background Accidental falls among people aged 65 years and older caused approximately
2,700,000 injuries, 27,000 deaths, and cost more than 34 billion dollars in the US annually in …
2,700,000 injuries, 27,000 deaths, and cost more than 34 billion dollars in the US annually in …