Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

B Zimmer, G Pallocca, N Dreser, S Foerster… - Archives of …, 2014 - Springer
Developmental toxicity in vitro assays have hitherto been established as stand-alone
systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel …

Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling

N Dreser, B Zimmer, C Dietz, E Sügis, G Pallocca… - Neurotoxicology, 2015 - Elsevier
Functional assays, such as the “migration inhibition of neural crest cells” (MINC) developmental
toxicity test, can identify toxicants without requiring knowledge on their mode of action (…

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

N Dreser, K Madjar, AK Holzer, M Kapitza, C Scholz… - Archives of …, 2020 - Springer
The first in vitro tests for developmental toxicity made use of rodent cells. Newer teratology
tests, eg developed during the ESNATS project, use human cells and measure mechanistic …

Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity

…, M Henry, AK Holzer, N Dreser… - Chemical research in …, 2017 - ACS Publications
Analysis of transcriptome changes has become an established method to characterize the
reaction of cells to toxicants. Such experiments are mostly performed at compound …

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research–Part I

AK Holzer, N Dreser, G Pallocca, A Mangerich… - ALTEX-Alternatives to …, 2023 - altex.org
Every test procedure, scientific and non-scientific, has inherent uncertainties, even when
performed according to a standard operating procedure (SOP). In addition, it is prone to errors, …

Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation

J Meisig, N Dreser, M Kapitza, M Henry… - Nucleic acids …, 2020 - academic.oup.com
Thousands of transcriptome data sets are available, but approaches for their use in dynamic
cell response modelling are few, especially for processes affected simultaneously by two …

High accuracy classification of developmental toxicants by in vitro tests of human neuroepithelial and cardiomyoblast differentiation

…, A Cherianidou, F Kappenberg, M Marta, N Dreser… - Cells, 2022 - mdpi.com
Human-relevant tests to predict developmental toxicity are urgently needed. A currently
intensively studied approach makes use of differentiating human stem cells to measure …

Early neurodevelopmental disturbances during sensitive periods of stem cell differentiation

N Dreser - 2020 - kops.uni-konstanz.de
The high need for appropriate in vitro tests for regulatory and industrial purposes as well as
the focused governmental and EU support leads to a constant increase in assays addressing …

[HTML][HTML] Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants

…, H Khalidi, I Gardner, GF Ecker, G Pallocca, N Dreser… - Cells, 2024 - mdpi.com
Cell-based test methods with a phenotypic readout are frequently used for toxicity screening.
However, guidance on how to validate the hits and how to integrate this information with …

Classification of developmental toxicants in a human iPSC transcriptomics-based test

…, F Seidel, F Kappenberg, N Dreser… - Chemical Research …, 2022 - ACS Publications
Despite the progress made in developmental toxicology, there is a great need for in vitro
tests that identify developmental toxicants in relation to human oral doses and blood …