Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery
B Zimmer, G Pallocca, N Dreser, S Foerster… - Archives of …, 2014 - Springer
Developmental toxicity in vitro assays have hitherto been established as stand-alone
systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel …
systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel …
Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling
Functional assays, such as the “migration inhibition of neural crest cells” (MINC) developmental
toxicity test, can identify toxicants without requiring knowledge on their mode of action (…
toxicity test, can identify toxicants without requiring knowledge on their mode of action (…
Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances
N Dreser, K Madjar, AK Holzer, M Kapitza, C Scholz… - Archives of …, 2020 - Springer
The first in vitro tests for developmental toxicity made use of rodent cells. Newer teratology
tests, eg developed during the ESNATS project, use human cells and measure mechanistic …
tests, eg developed during the ESNATS project, use human cells and measure mechanistic …
Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity
…, M Henry, AK Holzer, N Dreser… - Chemical research in …, 2017 - ACS Publications
Analysis of transcriptome changes has become an established method to characterize the
reaction of cells to toxicants. Such experiments are mostly performed at compound …
reaction of cells to toxicants. Such experiments are mostly performed at compound …
Acceptance criteria for new approach methods in toxicology and human health-relevant life science research–Part I
AK Holzer, N Dreser, G Pallocca, A Mangerich… - ALTEX-Alternatives to …, 2023 - altex.org
Every test procedure, scientific and non-scientific, has inherent uncertainties, even when
performed according to a standard operating procedure (SOP). In addition, it is prone to errors, …
performed according to a standard operating procedure (SOP). In addition, it is prone to errors, …
Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
J Meisig, N Dreser, M Kapitza, M Henry… - Nucleic acids …, 2020 - academic.oup.com
Thousands of transcriptome data sets are available, but approaches for their use in dynamic
cell response modelling are few, especially for processes affected simultaneously by two …
cell response modelling are few, especially for processes affected simultaneously by two …
High accuracy classification of developmental toxicants by in vitro tests of human neuroepithelial and cardiomyoblast differentiation
…, A Cherianidou, F Kappenberg, M Marta, N Dreser… - Cells, 2022 - mdpi.com
Human-relevant tests to predict developmental toxicity are urgently needed. A currently
intensively studied approach makes use of differentiating human stem cells to measure …
intensively studied approach makes use of differentiating human stem cells to measure …
Early neurodevelopmental disturbances during sensitive periods of stem cell differentiation
N Dreser - 2020 - kops.uni-konstanz.de
The high need for appropriate in vitro tests for regulatory and industrial purposes as well as
the focused governmental and EU support leads to a constant increase in assays addressing …
the focused governmental and EU support leads to a constant increase in assays addressing …
[HTML][HTML] Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants
…, H Khalidi, I Gardner, GF Ecker, G Pallocca, N Dreser… - Cells, 2024 - mdpi.com
Cell-based test methods with a phenotypic readout are frequently used for toxicity screening.
However, guidance on how to validate the hits and how to integrate this information with …
However, guidance on how to validate the hits and how to integrate this information with …
Classification of developmental toxicants in a human iPSC transcriptomics-based test
…, F Seidel, F Kappenberg, N Dreser… - Chemical Research …, 2022 - ACS Publications
Despite the progress made in developmental toxicology, there is a great need for in vitro
tests that identify developmental toxicants in relation to human oral doses and blood …
tests that identify developmental toxicants in relation to human oral doses and blood …