User profiles for Michael J. Wiser
Michael WiserMichigan State University Verified email at msu.edu Cited by 1599 |
Long-term dynamics of adaptation in asexual populations
Experimental studies of evolution have increased greatly in number in recent years, stimulated
by the growing power of genomic tools. However, organismal fitness remains the ultimate …
by the growing power of genomic tools. However, organismal fitness remains the ultimate …
Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load
Mutations are the ultimate source of heritable variation for evolution. Understanding how
mutation rates themselves evolve is thus essential for quantitatively understanding many …
mutation rates themselves evolve is thus essential for quantitatively understanding many …
A Comparison of Methods to Measure Fitness in Escherichia coli
In order to characterize the dynamics of adaptation, it is important to be able to quantify how
a population’s mean fitness changes over time. Such measurements are especially …
a population’s mean fitness changes over time. Such measurements are especially …
Sustained fitness gains and variability in fitness trajectories in the long-term evolution experiment with Escherichia coli
Many populations live in environments subject to frequent biotic and abiotic changes.
Nonetheless, it is interesting to ask whether an evolving population's mean fitness can increase …
Nonetheless, it is interesting to ask whether an evolving population's mean fitness can increase …
The MODES toolbox: Measurements of open-ended dynamics in evolving systems
Building more open-ended evolutionary systems can simultaneously advance our understanding
of biology, artificial life, and evolutionary computation. In order to do so, however, we …
of biology, artificial life, and evolutionary computation. In order to do so, however, we …
Fluctuating environments select for short-term phenotypic variation leading to long-term exploration
Genetic spaces are often described in terms of fitness landscapes or genotype-to-phenotype
maps, where each genetic sequence is associated with phenotypic properties and linked to …
maps, where each genetic sequence is associated with phenotypic properties and linked to …
Daily transfers, archiving populations, and measuring fitness in the long-term evolution experiment with Escherichia coli
…, JE Chavarria-Palma, M Izutsu, MJ Wiser - Journal of Visualized …, 2023 - par.nsf.gov
The Long-Term Evolution Experiment (LTEE) has followed twelve populations of Escherichia
coli as they have adapted to a simple laboratory environment for more than 35 years and …
coli as they have adapted to a simple laboratory environment for more than 35 years and …
The evolution of evolvability: Changing environments promote rapid adaptation in digital organisms
Genetic spaces are often described in terms of fitness landscapes or genotype-to- phenotype
maps, where each potential genetic sequence is associated with a set of properties and …
maps, where each potential genetic sequence is associated with a set of properties and …
An Avida-ED digital evolution curriculum for undergraduate biology
We present an inquiry-based curriculum based on the digital evolution platform Avida-ED (
http://avida-ed.msu.edu ). We designed an instructional sequence and lab book consisting of …
http://avida-ed.msu.edu ). We designed an instructional sequence and lab book consisting of …
Gene duplications drive the evolution of complex traits and regulation
Gene duplications have been shown to promote evolvability in biology and in computational
systems. We use digital evolution to explore why; that is, what characteristics of gene …
systems. We use digital evolution to explore why; that is, what characteristics of gene …