User profiles for Michael J. Wiser

Michael Wiser

Michigan State University
Verified email at msu.edu
Cited by 1599

Long-term dynamics of adaptation in asexual populations

MJ Wiser, N Ribeck, RE Lenski - Science, 2013 - science.org
Experimental studies of evolution have increased greatly in number in recent years, stimulated
by the growing power of genomic tools. However, organismal fitness remains the ultimate …

Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load

…, JE Barrick, O Tenaillon, MJ Wiser… - Proceedings of the …, 2013 - National Acad Sciences
Mutations are the ultimate source of heritable variation for evolution. Understanding how
mutation rates themselves evolve is thus essential for quantitatively understanding many …

A Comparison of Methods to Measure Fitness in Escherichia coli

MJ Wiser, RE Lenski - PloS one, 2015 - journals.plos.org
In order to characterize the dynamics of adaptation, it is important to be able to quantify how
a population’s mean fitness changes over time. Such measurements are especially …

Sustained fitness gains and variability in fitness trajectories in the long-term evolution experiment with Escherichia coli

RE Lenski, MJ Wiser, N Ribeck… - … of the Royal …, 2015 - royalsocietypublishing.org
Many populations live in environments subject to frequent biotic and abiotic changes.
Nonetheless, it is interesting to ask whether an evolving population's mean fitness can increase …

The MODES toolbox: Measurements of open-ended dynamics in evolving systems

EL Dolson, AE Vostinar, MJ Wiser, C Ofria - Artificial life, 2019 - direct.mit.edu
Building more open-ended evolutionary systems can simultaneously advance our understanding
of biology, artificial life, and evolutionary computation. In order to do so, however, we …

Fluctuating environments select for short-term phenotypic variation leading to long-term exploration

R Canino-Koning, MJ Wiser, C Ofria - PLoS computational biology, 2019 - journals.plos.org
Genetic spaces are often described in terms of fitness landscapes or genotype-to-phenotype
maps, where each genetic sequence is associated with phenotypic properties and linked to …

Daily transfers, archiving populations, and measuring fitness in the long-term evolution experiment with Escherichia coli

…, JE Chavarria-Palma, M Izutsu, MJ Wiser - Journal of Visualized …, 2023 - par.nsf.gov
The Long-Term Evolution Experiment (LTEE) has followed twelve populations of Escherichia
coli as they have adapted to a simple laboratory environment for more than 35 years and …

The evolution of evolvability: Changing environments promote rapid adaptation in digital organisms

R Canino-Koning, MJ Wiser, C Ofria - Artificial Life Conference …, 2016 - direct.mit.edu
Genetic spaces are often described in terms of fitness landscapes or genotype-to- phenotype
maps, where each potential genetic sequence is associated with a set of properties and …

An Avida-ED digital evolution curriculum for undergraduate biology

…, WR Johnson, AM Lark, LS Mead, MJ Wiser… - … Education and Outreach, 2016 - Springer
We present an inquiry-based curriculum based on the digital evolution platform Avida-ED (
http://avida-ed.msu.edu ). We designed an instructional sequence and lab book consisting of …

Gene duplications drive the evolution of complex traits and regulation

A Lalejini, MJ Wiser, C Ofria - Artificial Life Conference Proceedings, 2017 - direct.mit.edu
Gene duplications have been shown to promote evolvability in biology and in computational
systems. We use digital evolution to explore why; that is, what characteristics of gene …