User profiles for Makiko Kobayashi

Makiko Kobayashi

Kumamoto University
Verified email at cs.kumamoto-u.ac.jp
Cited by 1990

Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering

M Kobayashi, S Saitoh, N Tanimura… - The Journal of …, 2006 - journals.aai.org
LPS, a principal membrane component in Gram-negative bacteria, is recognized by a
receptor complex consisting of TLR4 and MD-2. MD-2 is an extracellular molecule that is …

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

…, T Arai, T Nishibata, M Kobayashi… - Molecular cancer …, 2009 - aacrjournals.org
Wee1 is a tyrosine kinase that phosphorylates and inactivates CDC2 and is involved in G 2
checkpoint signaling. Because p53 is a key regulator in the G 1 checkpoint, p53-deficient …

Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus

Y Tsuda, H Takahashi, M Kobayashi, T Hanafusa… - Immunity, 2004 - cell.com
Neutrophils (PMN) have been described as critical effector cells in the host's antibacterial
innate immunities. However, the classification of murine PMNs remains unclear. Here, we …

A pathogenic role of Th2 cells and their cytokine products on the pulmonary metastasis of murine B16 melanoma

M Kobayashi, H Kobayashi, RB Pollard… - The Journal of …, 1998 - academic.oup.com
The role of Th2 cells and the cytokines produced by these cells on experimental pulmonary
metastasis of B16 melanoma was investigated in a murine model implanted with high …

Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus

T Utsunomiya, M Kobayashi, RB Pollard… - Antimicrobial agents …, 1997 - journals.asm.org
The antiviral effect of glycyrrhizin (GR), an active component of licorice roots, was investigated
in mice infected with influenza virus A2 (H2N2). When mice that had been exposed to 10 …

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

…, T Arai, M Okada, T Nishibata, M Kobayashi… - Cancer biology & …, 2010 - Taylor & Francis
MK-1775 is a potent and selective small molecule Wee1 inhibitor. Previously we have shown
that it abrogated DNA damaged checkpoints induced by gemcitabine, carboplatin, and …

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll‐like receptor 4 (TLR4)‐MD‐2 and ligand‐induced TLR4 oligomerization

…, T Yamada, N Tanimura, M Kobayashi… - International …, 2004 - academic.oup.com
Toll‐like receptor 4 (TLR4) and MD‐2 recognizes lipid A, the active moiety of microbial
lipopolysaccharide (LPS). Little is known about mechanisms for LPS recognition by TLR4–MD‐2. …

Comprehensive electrocardiographic diagnosis based on deep learning

…, T Yamakawa, M Tanabe, M Kobayashi… - Artificial intelligence in …, 2020 - Elsevier
Cardiovascular disease (CVD) is the leading cause of death worldwide, and coronary artery
disease (CAD) is a major contributor. Early-stage CAD can progress if undiagnosed and left …

Neurotrophic function of conditioned medium from human amniotic epithelial cells

S Uchida, Y Inanaga, M Kobayashi… - Journal of …, 2000 - Wiley Online Library
Human amniotic epithelial cells (HAEC) may have pluripotent function because they are
formed from the epiblast cells at the 8th day of fertilization. Previously, we reported that HAEC …

CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages

T Katakura, M Miyazaki, M Kobayashi… - The Journal of …, 2004 - journals.aai.org
Classically activated macrophages (CAMφ) have been described as a major effector cell on
the host’s innate immunities. However, CAMφ are not generated in immunocompromised …