Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …

Conspectus For device miniaturization, nanotechnology follows either the “top-down”
approach scaling down existing larger-scale devices or the “bottom-up'approach …

The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang
II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The …

Organic aerosol (OA) particles affect climate forcing and human health, but their sources and
evolution remain poorly characterized. We present a unifying model framework describing …

Organic aerosol (OA) data acquired by the Aerosol Mass Spectrometer (AMS) in 37 field
campaigns were deconvolved into hydrocarbon‐like OA (HOA) and several types of …

Background Heightened surveillance of acute febrile illness in China since 2009 has led to
the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an …

Giucocorticoids are potent inhibitors of coiiagenase induction by phorbol esters and
inflammatory mediators. The target for this negatlve effect is the AP1 site within the …

INTERACTIONS between cytokine and receptor lead to the activation of multiple signalling
molecules, including the family of signal transducer and activator of transcription (STAT) …

Purpose: Although clinical studies have shown promise for targeting programmed cell death
protein-1 (PD-1) and ligand (PD-L1) signaling in non–small cell lung cancer (NSCLC), the …

The performance of ad hoc networks depends on cooperation and trust among distributed
nodes. To enhance security in ad hoc networks, it is important to evaluate trustworthiness of …