To define the genetic requirements for pancreatic ductal adenocarcinoma (PDA), we have
targeted concomitant endogenous expression of Trp53 R172H and Kras G12D to the mouse …

Werner Syndrome (WS) is a premature aging syndrome characterized by early onset of age-
related pathologies and cancer. Since WS is due to a single gene defect, it has attracted …

The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not
yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript …

Mutational inactivation of the gene WRN causes Werner syndrome, an autosomal recessive
disease characterized by premature aging, elevated genomic instability and increased …

The terminal t-loop structure adopted by mammalian telomeres is thought to prevent
telomeres from being recognized as double-stranded DNA breaks by sequestering the 3 …

We investigated genome folding across the eukaryotic tree of life. We find two types of three-
dimensional (3D) genome architectures at the chromosome scale. Each type appears and …

Dysfunctional telomeres induce p53‐dependent cellular senescence and apoptosis, but it is
not known which function is more important for tumour suppression in vivo. We used the p53 …

HIV-1 integration into the host genome favors actively transcribed genes. Prior work
indicated that the nuclear periphery provides the architectural basis for integration site …

Abstract REST/NRSF (repressor-element-1-silencing transcription factor/neuron-restrictive
silencing factor) negatively regulates the transcription of genes containing RE1 sites,. REST …

Epigenetic dysregulation has emerged as a major contributor to tumorigenesis. Histone
methylation is a well-established mechanism of epigenetic regulation that is dynamically …