User profiles for "author:Menegas W"
 | William MenegasResearch Scientist, Broad Institute of MIT and Harvard Verified email at broadinstitute.org Cited by 1712 |
Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass
Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet
imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to …
imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to …
Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice
Dopamine neurons are thought to encode novelty in addition to reward prediction error (the
discrepancy between actual and predicted values). In this study, we compared dopamine …
discrepancy between actual and predicted values). In this study, we compared dopamine …
Multi-animal pose estimation, identification and tracking with DeepLabCut
Estimating the pose of multiple animals is a challenging computer vision problem: frequent
interactions cause occlusions and complicate the association of detected keypoints to the …
interactions cause occlusions and complicate the association of detected keypoints to the …
Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli
Midbrain dopamine neurons are well known for their role in reward-based reinforcement
learning. We found that the activity of dopamine axons in the posterior tail of the striatum …
learning. We found that the activity of dopamine axons in the posterior tail of the striatum …
Atypical behaviour and connectivity in SHANK3-mutant macaques
Mutation or disruption of the SH3 and ankyrin repeat domains 3 (SHANK3) gene represents
a highly penetrant, monogenic risk factor for autism spectrum disorder, and is a cause of …
a highly penetrant, monogenic risk factor for autism spectrum disorder, and is a cause of …
Multi-animal pose estimation and tracking with DeepLabCut
Estimating the pose of multiple animals is a challenging computer vision problem: frequent
interactions cause occlusions and complicate the association of detected keypoints to the …
interactions cause occlusions and complicate the association of detected keypoints to the …
Planar-polarized semaphorin-5c and plexin A promote the collective migration of epithelial cells in Drosophila
Collective migration of epithelial cells is essential for morphogenesis, wound repair, and the
spread of many cancers, yet how individual cells signal to one another to coordinate their …
spread of many cancers, yet how individual cells signal to one another to coordinate their …
A Screen for Round Egg Mutants in Drosophila Identifies Tricornered, Furry, and Misshapen as Regulators of Egg Chamber Elongation
S Horne-Badovinac, J Hill, G Gerlach… - G3: Genes …, 2012 - academic.oup.com
The elongation of tissues and organs during embryonic development results from the
coordinate polarization of cell behaviors with respect to the elongation axis. Within the …
coordinate polarization of cell behaviors with respect to the elongation axis. Within the …
Evaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus)
NJ Fabian, AJ Mannion, M Jamiel, DJ Anderson… - Scientific Reports, 2023 - nature.com
While sustained-release buprenorphine (BSR) is used as a long-lasting opioid analgesic in
common marmosets (Callithrix jacchus), there are no published studies on pharmaceutical …
common marmosets (Callithrix jacchus), there are no published studies on pharmaceutical …
High-throughput unsupervised quantification of patterns in the natural behavior of marmosets
Recent advances in genetic engineering have accelerated the production of nonhuman
primate models for neuropsychiatric disorders. To use these models for preclinical drug …
primate models for neuropsychiatric disorders. To use these models for preclinical drug …