The leucine-rich repeat is a widespread structural motif of 20–30 amino acids with a
characteristic repetitive sequence pattern rich in leucines. Leucine-rich repeat domains are …

Abstract The interface of protein structural biology, protein biophysics, molecular evolution,
and molecular population genetics forms the foundations for a mechanistic understanding of …

Protein–protein interactions effectively mediate molecular function. They are the result of
specific interactions between protein interfaces and are maintained by the action of …

Geometrical validation around the C is described, with a new C measure and updated
Ramachandran plot. Deviation of the observed C atom from ideal position provides a single …

This paper describes the current update on macromolecular model validation services that
are provided at the MolProbity website, emphasizing changes and additions since the …

Small-probe contact dot surface analysis, with all explicit hydrogen atoms added and their
van der Waals contacts included, was used to choose between the two possible orientations …

All published rotamer libraries contain some rotamers that exhibit impossible internal atomic
overlaps if built in ideal geometry with all hydrogen atoms. Removal of uncertain residues …

Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of
adenosine to inosine in double-stranded RNA (dsRNA) and thereby potentially alter the …

The technique of small-probe contact dot surfaces is described as a method for calculating
and displaying the detailed atomic contacts inside or between molecules. It allows one both …

Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and
gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1 …