The dopamine system is unique among the brain's modulatory systems in that it has discrete
projections to specific brain regions involved in motor behaviour, cognition and emotion …

There are several brain regions that have been implicated in the control of motivated
behavior and whose disruption leads to the pathophysiology observed in major psychiatric …

Although first thought of as a dopaminergic disorder, there is little direct evidence to support
a primary pathology in the dopamine system as the etiological factor in schizophrenia. In …

Goal-directed behavior is believed to involve interactions of prefrontal cortical and limbic
inputs in the nucleus accumbens (NAcc), and their modulation by mesolimbic dopamine …

In this article we develop the concept that the hippocampus and the midbrain dopaminergic
neurons of the ventral tegmental area (VTA) form a functional loop. Activation of the loop …

A novel mechanism for regulating dopamine activity in subcortical sites and its possible
relevance to schizophrenia is proposed. This hypothesis is based on the regulation of …

In addition to firing in a single spiking mode, dopamine (DA) cells have been observed to fire
in a bursting pattern with consecutive spikes in a burst displaying progressively decreasing …

Background Implantable cardioverter–defibrillators (ICDs) prevent sudden death from
cardiac causes in selected patients but require the use of transvenous lead systems. To …

The mesolimbic dopamine system is centrally involved in reward and goal-directed
behavior, and it has been implicated in multiple psychiatric disorders. Understanding the …

Many risk genes interact synergistically to produce schizophrenia and many
neurotransmitter interactions have been implicated. We have developed a circuit-based …