Exposure to microbes during early childhood is associated with protection from immune-
mediated diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show …

Regulatory T cells (Tregs) that express the transcription factor Foxp3 are critical for
regulating intestinal inflammation. Candidate microbe approaches have identified bacterial …

Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses
indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma …

Inflammatory bowel disease (IBD) has been attributed to overexuberant host immunity or the
emergence of harmful intestinal flora. The transcription factor T-bet orchestrates …

Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the
intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic …

Background It is a challenge to identify patients who, after undergoing potentially curative
treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk …

Although mast cell functions have classically been related to allergic responses,,, recent
studies indicate that these cells contribute to other common diseases such as multiple …

Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We
observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of …

Pancreatic ductal adenocarcinoma (PDAC), an epithelial neoplasm derived from the
pancreatic ductal tree, is the most common histologic type of pancreatic cancer and …

Disruption of homeostasis between the host immune system and the intestinal microbiota
leads to inflammatory bowel disease (IBD). Whether IBD is instigated by individual species …