Improved free-energy parameters for predictions of RNA duplex stability.
SM Freier, R Kierzek, JA Jaeger, N Sugimoto… - Proceedings of the …, 1986 - pnas.org
Thermodynamic parameters for prediction of RNA duplex stability are reported. One
parameter for duplex initiation and 10 parameters for helix propagation are derived from …
parameter for duplex initiation and 10 parameters for helix propagation are derived from …
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
DNA ANALOGUES are currently being intensely investigated owing to their potential as
gene-targeted drugs1–3. Furthermore, their properties and interaction with DNA and RNA …
gene-targeted drugs1–3. Furthermore, their properties and interaction with DNA and RNA …
The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …
MicroRNA-143 regulates adipocyte differentiation
C Esau, X Kang, E Peralta, E Hanson… - Journal of Biological …, 2004 - jbc.org
MicroRNAs (miRNAs) are endogenously expressed 20-24 nucleotide RNAs thought to
repress protein translation through binding to a target mRNA (1-3). Only a few of the more …
repress protein translation through binding to a target mRNA (1-3). Only a few of the more …
Evaluation of 2 '-modified oligonucleotides containing 2 '-deoxy gaps as antisense inhibitors of gene expression
BP Monia, EA Lesnik, C Gonzalez, WF Lima… - Journal of Biological …, 1993 - jbc.org
We have used a previously described 17-mer phosphorothioate (Monia, BP, Johnston, JF,
Ecker, DJ, Zounes, MA, Lima, WF, and Freier, SM (1992) J. Biol. Chem. 267, 19954-19962) …
Ecker, DJ, Zounes, MA, Lima, WF, and Freier, SM (1992) J. Biol. Chem. 267, 19954-19962) …
The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA: RNA duplexes
SM Freier, KH Altmann - Nucleic acids research, 1997 - academic.oup.com
In an effort to discover novel oligonucleotide modifications for antisense therapeutics, we
have prepared oligodeoxyribonucleotides containing more than 200 different modifications …
have prepared oligodeoxyribonucleotides containing more than 200 different modifications …
Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB
V Tripathi, Z Shen, A Chakraborty, S Giri… - PLoS …, 2013 - journals.plos.org
The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated
expression is associated with hyper-proliferation, but the underlying mechanism is poorly …
expression is associated with hyper-proliferation, but the underlying mechanism is poorly …
3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA
JE Wilusz, SM Freier, DL Spector - Cell, 2008 - cell.com
MALAT1 is a long noncoding RNA known to be misregulated in many human cancers. We
have identified a highly conserved small RNA of 61 nucleotides originating from the …
have identified a highly conserved small RNA of 61 nucleotides originating from the …
[HTML][HTML] Regulating gene expression through RNA nuclear retention
Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified
CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …
CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …
Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets
AM Kawasaki, MD Casper, SM Freier… - Journal of medicinal …, 1993 - ACS Publications
“Uniformly” modified phosphodiester or phosphorothioate oligonucleotides incorporating 2'-
deoxy-2'-fluoroadenosine,-guanosine,-uridine, and-cytidine, reported herein for the first time …
deoxy-2'-fluoroadenosine,-guanosine,-uridine, and-cytidine, reported herein for the first time …