We present an update to our Galaxy-based web server for processing and visualizing
deeply sequenced data. Its core tool set, deepTools, allows users to perform complete …

We present a Galaxy based web server for processing and visualizing deeply sequenced
data. The web server's core functionality consists of a suite of newly developed tools, called …

Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the
functional effector or memory T cell states,,,,–. Here we identify the nuclear factor TOX as a …

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells. How autoimmune T cell populations arise and are …

Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …

T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed
a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor …

Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes
derived from recurrently mutated driver genes. Here we describe a high-throughput platform …

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …

Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental
trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To …

Due to an inability to ethically access developing human brain tissue as well as identify
prospective cases, early-arising neurodevelopmental and cell-specific signatures of …