Frailty is a commonly used term indicating older persons at increased risk for adverse
outcomes such as onset of disability, morbidity, institutionalisation or mortality or who …

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …

Although it is known that Parkinson's disease results from a loss of dopaminergic neurons in
the substantia nigra, the resulting alterations in activity in the basal ganglia responsible for …

The biotic ligand model (BLM) of acute metal toxicity to aquatic organisms is based on the
idea that mortality occurs when the metal—biotic ligand complex reaches a critical …

Background: There is no single generally accepted clinical definition of frailty. Previously
developed tools to assess frailty that have been shown to be predictive of death or need for …

Psychometric properties of the 11-item self-report Drug Use Disorders Identification Test
(DUDIT) were evaluated in a sample of heavy drug users from prison, probation, and …

1. The neuronal mechanisms underlying the major motor signs of Parkinson's disease were
studied in the basal ganglia of parkinsonian monkeys. Three African green monkeys were …

Clinicians and researchers have shown increasing interest in frailty. Yet, there is still
considerable uncertainty regarding the concept and its definition. In this article, we present …

IT is possible that brain cortical function is mediated by dynamic modulation of coherent
firing in groups of neurons. Indeed, a correlation of firing between cortical neurons, seen …