Sodium butyrate improves cognitive dysfunction in high-fat diet/streptozotocin-induced type 2 diabetic mice by ameliorating hippocampal mitochondrial damage …

LL Lu, LZ Liu, L Li, YY Hu, XH Xian, WB Li - Neuropharmacology, 2024 - Elsevier
Cognitive dysfunction is an important comorbidity of type 2 diabetes mellitus (T2DM).
Sodium butyrate (NaB) is a short-chain fatty acid and has an effect improving T2DM …

Fecal microbiota transplantation and short-chain fatty acids improve learning and memory in fluorosis mice by BDNF-PI3K/AKT pathway

T Zhao, J Lv, M Peng, J Mi, S Zhang, J Liu… - Chemico-Biological …, 2024 - Elsevier
Fluoride, an environmental toxicant, not only arouses intestinal microbiota dysbiosis, but
also causes neuronal apoptosis and a decline in learning and memory ability. The purpose …

The Role of GSK3β Signaling Mediated Lysosomal Biosynthesis Dysregulation in Fluoride-Induced Neurological Impairment

Y Cheng, Y Du, Y Hu, X Wang, Q Li, X Yan… - Food and Chemical …, 2025 - Elsevier
Neurological dysfunction induced by fluoride is still one of major concern worldwide, yet the
underlying mechanisms remain elusive. To explore whether fluoride disrupts lysosomal …

[HTML][HTML] Sodium butyrate attenuates oxidative stress, apoptosis, and excessive mitophagy in sodium fluoride-induced hepatotoxicity in rats

J Xia, X Zhang, L Xu, N Yan, Z Sun, X Duan… - Ecotoxicology and …, 2025 - Elsevier
Aim Long-term exposure to excess sodium fluoride (NaF) can cause chronic fluorosis. Liver,
the most important detoxification organ, is the most vulnerable to the effects of fluoride …

Proteomics Sequencing Reveals the Role of TGF-β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride

F Yu, S Yu, L Duan, S Yang, X Hou, Y Du… - … Trace Element Research, 2024 - Springer
The underlying mechanism of fluorosis has not been fully elucidated. The purpose of this
study was to explore the mechanism of fluorosis induced by sodium fluoride (NaF) using …

[HTML][HTML] Fluoride Alters Gene Expression via Histone H3K27 Acetylation in Ameloblast-like LS8 Cells

S Yamashita, M Okamoto, M Mendonca… - International Journal of …, 2024 - mdpi.com
Excessive fluoride ingestion during tooth development can cause dental fluorosis.
Previously, we reported that fluoride activates histone acetyltransferase (HAT) to acetylate …

Metabolic shift as a compensatory response to impaired hippocampal neurogenesis after developmental exposure to sodium fluoride in rats

M Shobudani, Y Sakamaki, A Karasawa, R Ojiro… - Acta …, 2024 - Elsevier
Fluoride affects neurodevelopment in children. In this study, we examined the effects of
developmental exposure to sodium fluoride (NaF) on hippocampal neurogenesis in rats …

Uncovering novel therapeutic targets in glucose, nucleotides and lipids metabolism during cancer and neurological diseases

SM Jovičić - International Journal of Immunopathology and …, 2024 - journals.sagepub.com
Background Cell metabolism functions without a stop in normal and pathological cells.
Different metabolic changes occur in the disease. Cell metabolism influences biochemical …

The Pathophysiological Changes and Clinical Effects of Tetramethylpyrazine in ICR Mice with Fluoride-Induced Hepatopathy

S Zhang, Y Zheng, H Du, W Zhang, H Li, Y Ou, F Xu… - Molecules, 2023 - mdpi.com
The excessive intake of fluoride, one of the trace elements required to maintain health, leads
to liver injury. Tetramethylpyrazine (TMP) is a kind of traditional Chinese medicine monomer …