Potency assays and biomarkers for cell-based advanced therapy medicinal products
C Capelli, C Cuofano, C Pavoni, S Frigerio… - Frontiers in …, 2023 - frontiersin.org
Advanced Therapy Medicinal Products (ATMPs) based on somatic cells expanded in vitro,
with or without genetic modification, is a rapidly growing area of drug development, even …
with or without genetic modification, is a rapidly growing area of drug development, even …
Spinal cord organoids to study motor neuron development and disease
F Buchner, Z Dokuzluoglu, T Grass… - Life, 2023 - mdpi.com
Motor neuron diseases (MNDs) are a heterogeneous group of disorders that affect the
cranial and/or spinal motor neurons (spMNs), spinal sensory neurons and the muscular …
cranial and/or spinal motor neurons (spMNs), spinal sensory neurons and the muscular …
[HTML][HTML] mRNA-mediated delivery of gene editing tools to human primary muscle stem cells
C Stadelmann, S Di Francescantonio, A Marg… - … Therapy-Nucleic Acids, 2022 - cell.com
Muscular dystrophies are approximately 50 devastating, untreatable monogenic diseases
leading to progressive muscle degeneration and atrophy. Gene correction of transplantable …
leading to progressive muscle degeneration and atrophy. Gene correction of transplantable …
Duchenne muscular dystrophy disease severity impacts skeletal muscle progenitor cells systemic delivery
Duchenne muscular dystrophy (DMD) is caused by an out-of-frame mutation in the DMD
gene that results in the absence of a functional dystrophin protein, leading to a devastating …
gene that results in the absence of a functional dystrophin protein, leading to a devastating …
How Can Proteomics Help to Elucidate the Pathophysiological Crosstalk in Muscular Dystrophy and Associated Multi-System Dysfunction?
P Dowling, C Trollet, E Negroni, D Swandulla… - Proteomes, 2024 - mdpi.com
This perspective article is concerned with the question of how proteomics, which is a core
technique of systems biology that is deeply embedded in the multi-omics field of modern …
technique of systems biology that is deeply embedded in the multi-omics field of modern …
Endomysium-permeable muscle extracellular matrix composite hydrogel for promoting functional muscle recovery in muscle atrophy
Sarcopenia is an age-related muscle atrophy that has recently been considered a significant
factor in deteriorating the quality of life in elderly individuals. However, currently, there are …
factor in deteriorating the quality of life in elderly individuals. However, currently, there are …
Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species
Stem cell transplantation presents a potentially curative strategy for genetic disorders of
skeletal muscle, but this approach is limited by the deleterious effects of cell expansion in …
skeletal muscle, but this approach is limited by the deleterious effects of cell expansion in …
[HTML][HTML] Cellular pathogenesis of Duchenne muscular dystrophy: progressive myofibre degeneration, chronic inflammation, reactive myofibrosis and satellite cell …
P Dowling, D Swandulla… - European Journal of …, 2023 - ncbi.nlm.nih.gov
Duchenne muscular dystrophy is a highly progressive muscle wasting disease of early
childhood and characterized by complex pathophysiological and histopathological changes …
childhood and characterized by complex pathophysiological and histopathological changes …
Comparison of Muscle Regeneration after BMSC-Conditioned Medium, Syngeneic, or Allogeneic BMSC Injection
B Świerczek-Lasek, L Tolak, L Bijoch, M Stefaniuk… - Cells, 2022 - mdpi.com
For many years optimal treatment for dysfunctional skeletal muscle characterized, for
example, by impaired or limited regeneration, has been searched. Among the crucial factors …
example, by impaired or limited regeneration, has been searched. Among the crucial factors …
[HTML][HTML] Myopathies in broilers: supply chain approach to provide solutions to challenges related to raising fast growing birds
S Barbut, R Mitchell, P Hall, C Bacon, R Bailey… - Poultry Science, 2024 - Elsevier
This review is a summary of a Poultry Science Association symposium addressing
myopathies in broilers' breast meat, focusing on the interactions between genetics, nutrition …
myopathies in broilers' breast meat, focusing on the interactions between genetics, nutrition …