Advances in optical detection of human-associated pathogenic bacteria

A Locke, S Fitzgerald, A Mahadevan-Jansen - Molecules, 2020 - mdpi.com
Bacterial infection is a global burden that results in numerous hospital visits and deaths
annually. The rise of multi-drug resistant bacteria has dramatically increased this burden …

Optical coherence tomography of the tympanic membrane and middle ear: a review

HEI Tan, PL Santa Maria… - … –Head and Neck …, 2018 - journals.sagepub.com
Objective To evaluate the recent developments in optical coherence tomography (OCT) for
tympanic membrane (TM) and middle ear (ME) imaging and to identify what further …

Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements

GL Monroy, J Won, DR Spillman Jr… - … of biomedical optics, 2017 - spiedigitallibrary.org
Since the inception of optical coherence tomography (OCT), advancements in imaging
system design and handheld probes have allowed for numerous advancements in disease …

Differentiation of otitis media-causing bacteria and biofilms via Raman spectroscopy and optical coherence tomography

AK Locke, FR Zaki, ST Fitzgerald, K Sudhir… - Frontiers in Cellular …, 2022 - frontiersin.org
In the management of otitis media (OM), identification of causative bacterial pathogens and
knowledge of their biofilm formation can provide more targeted treatment approaches …

Automated classification platform for the identification of otitis media using optical coherence tomography

GL Monroy, J Won, R Dsouza, P Pande, MC Hill… - NPJ digital …, 2019 - nature.com
The diagnosis and treatment of otitis media (OM), a common childhood infection, is a
significant burden on the healthcare system. Diagnosis relies on observer experience via …

New approaches and technologies to improve accuracy of acute otitis media diagnosis

S Esposito, S Bianchini, A Argentiero, R Gobbi, C Vicini… - Diagnostics, 2021 - mdpi.com
Several studies have shown that in recent years incidence of acute otitis media (AOM) has
declined worldwide. However, related medical, social, and economic problems for patients …

Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

GL Monroy, P Pande, RM Nolan… - … of biomedical optics, 2017 - spiedigitallibrary.org
In an institutional review board-approved study, 25 pediatric subjects diagnosed with
chronic or recurrent otitis media were observed over a period of six months with optical …

Direct analysis of pathogenic structures affixed to the tympanic membrane during chronic otitis media

GL Monroy, W Hong, P Khampang… - … –Head and Neck …, 2018 - journals.sagepub.com
Objective To characterize otitis media–associated structures affixed to the mucosal surface
of the tympanic membrane (TM) in vivo and in surgically recovered in vitro samples. Study …

Multimodal handheld probe for characterizing otitis media—integrating Raman spectroscopy and optical coherence tomography

GL Monroy, ST Fitzgerald, A Locke, J Won… - Frontiers in …, 2022 - frontiersin.org
Otitis media (OM) is a common disease of the middle ear, affecting 80% of children before
the age of three. The otoscope, a simple illuminated magnifier, is the standard clinical …

Texture‐based speciation of otitis media‐related bacterial biofilms from optical coherence tomography images using supervised classification

FR Zaki, GL Monroy, J Shi, K Sudhir… - Journal of …, 2024 - Wiley Online Library
Otitis media (OM), a highly prevalent inflammatory middle‐ear disease in children
worldwide, is commonly caused by an infection, and can lead to antibiotic‐resistant bacterial …