Metabolomics: the apogee of the omics trilogy

GJ Patti, O Yanes, G Siuzdak - Nature reviews Molecular cell biology, 2012 - nature.com
Metabolites, the chemical entities that are transformed during metabolism, provide a
functional readout of cellular biochemistry. With emerging technologies in mass …

Metabolomics technology and bioinformatics for precision medicine

RK Azad, V Shulaev - Briefings in bioinformatics, 2019 - academic.oup.com
Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small
group or even individual patients based on their genetics, environment and lifestyle …

High-resolution liquid chromatography tandem mass spectrometry enables large scale molecular characterization of dissolved organic matter

D Petras, I Koester, R Da Silva, BM Stephens… - Frontiers in Marine …, 2017 - frontiersin.org
Dissolved organic matter (DOM) is arguably one of the most complex exometabolomes on
earth, and is comprised of thousands of compounds, that together contribute more than 600× …

Application of NMR metabolomics to search for human disease biomarkers

T Gebregiworgis, R Powers - Combinatorial chemistry & high …, 2012 - ingentaconnect.com
Since antiquity, humans have used body fluids like saliva, urine and sweat for the diagnosis
of diseases. The amount, color and smell of body fluids are still used in many traditional …

Beyond metabolomics: a review of multi-omics-based approaches

DJ Beale, AV Karpe, W Ahmed - Microbial metabolomics: Applications in …, 2016 - Springer
Genomics and transcriptonomics studies have been the cornerstones of numerous
biological progresses in several decades. Additionally, proteomic studies, especially related …

Xenobiotic metabolism: a view through the metabolometer

AD Patterson, FJ Gonzalez, JR Idle - Chemical research in …, 2010 - ACS Publications
The combination of advanced ultraperformance liquid chromatography coupled with mass
spectrometry, chemometrics, and genetically modified mice provide an attractive raft of …

Metabolomic profiling of asthma and chronic obstructive pulmonary disease: a pilot study differentiating diseases

DJ Adamko, P Nair, I Mayers, RT Tsuyuki… - Journal of Allergy and …, 2015 - Elsevier
Background Differentiating asthma from other causes of chronic airflow limitation, such as
chronic obstructive pulmonary disease (COPD), can be difficult in a typical outpatient setting …

The metabolomics of airway diseases, including COPD, asthma and cystic fibrosis

BF Nobakht M. Gh, R Aliannejad, M Rezaei-Tavirani… - Biomarkers, 2015 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are
characterized by airway obstruction and an inflammatory process. Reaching early diagnosis …

ConCISE: Consensus Annotation Propagation of Ion Features in Untargeted Tandem Mass Spectrometry Combining Molecular Networking and In Silico Metabolite …

ZA Quinlan, I Koester, AT Aron, D Petras, LI Aluwihare… - Metabolites, 2022 - mdpi.com
Recent developments in molecular networking have expanded our ability to characterize the
metabolome of diverse samples that contain a significant proportion of ion features with no …

Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy

EJ Saude, CD Skappak, S Regush, K Cook… - Journal of allergy and …, 2011 - Elsevier
BACKGROUND: The ability to diagnose and monitor asthma on the basis of noninvasive
measurements of airway cellular dysfunction is difficult in the typical clinical setting …