Krüppel-like factor 4 (KLF4): What we currently know
AM Ghaleb, VW Yang - Gene, 2017 - Elsevier
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …
transcription factor that regulates diverse cellular processes such as cell growth …
Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer
AR Black, JD Black… - Journal of cellular …, 2001 - Wiley Online Library
The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …
Strategies and new developments in the generation of patient-specific pluripotent stem cells
S Yamanaka - Cell stem cell, 2007 - cell.com
Generating pluripotent stem cells directly from cells obtained from patients is one of the
ultimate goals in regenerative medicine. Two" reprogramming" strategies for the generation …
ultimate goals in regenerative medicine. Two" reprogramming" strategies for the generation …
KLF4 transcription factor in tumorigenesis
Z He, J He, K Xie - Cell death discovery, 2023 - nature.com
Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of
Krüppel-like transcriptional factor usually causes abnormal embryonic development and …
Krüppel-like transcriptional factor usually causes abnormal embryonic development and …
A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …
Klf4 is a transcription factor required for establishing the barrier function of the skin
JA Segre, C Bauer, E Fuchs - Nature genetics, 1999 - nature.com
Located at the interface between body and environment, the epidermis must protect the
body against toxic agents and dehydration, and protect itself against physical and …
body against toxic agents and dehydration, and protect itself against physical and …
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
JP Katz, N Perreault, BG Goldstein, CS Lee… - 2002 - journals.biologists.com
Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin,
lungs, gastrointestinal tract and several other organs. In vitro studies have suggested that …
lungs, gastrointestinal tract and several other organs. In vitro studies have suggested that …
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
BD Rowland, R Bernards, DS Peeper - Nature cell biology, 2005 - nature.com
Abstract KLF4 (GKLF/EZF) encodes a transcription factor that is associated with both tumour
suppression and oncogenesis. We describe the identification of KLF4 in a functional …
suppression and oncogenesis. We describe the identification of KLF4 in a functional …
Krüppel-like factors: three fingers in many pies
JJ Bieker - Journal of Biological Chemistry, 2001 - ASBMB
Krüppel-like factors (KLFs) 1 are DNA-binding transcriptional regulators that play diverse
roles during differentiation and development. They form a subset of the broad class of …
roles during differentiation and development. They form a subset of the broad class of …
KLF4, p21 and context-dependent opposing forces in cancer
BD Rowland, DS Peeper - Nature Reviews Cancer, 2006 - nature.com
Krüppel-like factors are transcriptional regulators that influence several cellular functions,
including proliferation. Recent studies have shown that one family member, KLF4, can …
including proliferation. Recent studies have shown that one family member, KLF4, can …