Krüppel-like factor 4 (KLF4): What we currently know

AM Ghaleb, VW Yang - Gene, 2017 - Elsevier
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer

AR Black, JD Black… - Journal of cellular …, 2001 - Wiley Online Library
The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …

Strategies and new developments in the generation of patient-specific pluripotent stem cells

S Yamanaka - Cell stem cell, 2007 - cell.com
Generating pluripotent stem cells directly from cells obtained from patients is one of the
ultimate goals in regenerative medicine. Two" reprogramming" strategies for the generation …

KLF4 transcription factor in tumorigenesis

Z He, J He, K Xie - Cell death discovery, 2023 - nature.com
Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of
Krüppel-like transcriptional factor usually causes abnormal embryonic development and …

A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog

JK Ichida, J Blanchard, K Lam, EY Son, JE Chung… - Cell stem cell, 2009 - cell.com
The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …

Klf4 is a transcription factor required for establishing the barrier function of the skin

JA Segre, C Bauer, E Fuchs - Nature genetics, 1999 - nature.com
Located at the interface between body and environment, the epidermis must protect the
body against toxic agents and dehydration, and protect itself against physical and …

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon

JP Katz, N Perreault, BG Goldstein, CS Lee… - 2002 - journals.biologists.com
Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin,
lungs, gastrointestinal tract and several other organs. In vitro studies have suggested that …

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

BD Rowland, R Bernards, DS Peeper - Nature cell biology, 2005 - nature.com
Abstract KLF4 (GKLF/EZF) encodes a transcription factor that is associated with both tumour
suppression and oncogenesis. We describe the identification of KLF4 in a functional …

Krüppel-like factors: three fingers in many pies

JJ Bieker - Journal of Biological Chemistry, 2001 - ASBMB
Krüppel-like factors (KLFs) 1 are DNA-binding transcriptional regulators that play diverse
roles during differentiation and development. They form a subset of the broad class of …

KLF4, p21 and context-dependent opposing forces in cancer

BD Rowland, DS Peeper - Nature Reviews Cancer, 2006 - nature.com
Krüppel-like factors are transcriptional regulators that influence several cellular functions,
including proliferation. Recent studies have shown that one family member, KLF4, can …