High-fat diet and female fertility across lifespan: a comparative lesson from mammal models

C Di Berardino, A Peserico, G Capacchietti… - Nutrients, 2022 - mdpi.com
Female reproduction focuses mainly on achieving fully grown follicles and competent
oocytes to be successfully fertilized, as well as on nourishing the developing offspring once …

Developmental effects of (pre-) gestational diabetes on offspring: systematic screening using omics approaches

B Shashikadze, F Flenkenthaler, JB Stöckl, L Valla… - Genes, 2021 - mdpi.com
Worldwide, gestational diabetes affects 2–25% of pregnancies. Due to related disturbances
of the maternal metabolism during the periconceptional period and pregnancy, children bear …

Obesity alters the ovarian proteomic response to zearalenone exposure

ME González-Alvarez, BC McGuire… - Biology of …, 2021 - academic.oup.com
Zearalenone (ZEN), a nonsteroidal estrogenic mycotoxin, is detrimental to female
reproduction. Altered chemical biotransformation, depleted primordial follicles and a blunted …

PFOA-induced ovotoxicity differs between lean and obese mice with impacts on ovarian reproductive and DNA damage sensing and repair proteins

M Estefanía González-Alvarez, A Severin… - Toxicological …, 2022 - academic.oup.com
Perfluorooctanoic acid (PFOA) is an environmentally persistent perfluoroalkyl substance that
is widely used in consumer products. Exposure to PFOA is associated with reproductive and …

A novel model of gestational diabetes: Acute high fat high sugar diet results in insulin resistance and beta cell dysfunction during pregnancy in mice

A Mishra, SH Ruano, PK Saha, KA Pennington - PloS One, 2022 - journals.plos.org
Gestational diabetes mellitus (GDM) affects 7–18% of all pregnancies. Despite its high
prevalence, there is no widely accepted animal model. To address this, we recently …

Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal …

KL Clark, JS Davis - Toxicology and applied pharmacology, 2022 - Elsevier
Perfluorooctanoic acid (PFOA) is a synthetic chemical resistant to biodegradation and is
environmentally persistent. PFOA is found in many consumer products and is a major source …

An ovarian phenotype of alpha 7 nicotinic receptor knockout mice

P Seßenhausen, KM Caban, N Kreitmair… - …, 2023 - rep.bioscientifica.com
In brief Nicotinic acetylcholine receptor alpha 7 (nAChRa7), encoded by Chrna7, is
expressed by various murine ovarian cells. Morphological and molecular investigations …

Hepatic and ovarian effects of perfluorooctanoic acid exposure differ in lean and obese adult female mice

ME González-Alvarez, AF Keating - Toxicology and Applied Pharmacology, 2023 - Elsevier
Obesity and overweight cause poor oocyte quality, miscarriage, infertility, polycystic ovarian
syndrome, and offspring birth defects and affects 40% and 20% of US women and girls …

Looking at the future through the mother's womb: gestational diabetes and offspring fertility

N Sinha, G Lydia Walker, A Sen - Endocrinology, 2021 - academic.oup.com
Altered nutrition or intrauterine exposure to various adverse conditions during fetal
development or earlier in a mother's life can lead to epigenetic changes in fetal tissues …

Transcription factor PLAGL1 is associated with angiogenic gene expression in the placenta

RR Starks, R Abu Alhasan, H Kaur… - International journal of …, 2020 - mdpi.com
During pregnancy, the placenta is important for transporting nutrients and waste between
the maternal and fetal blood supply, secreting hormones, and serving as a protective barrier …