Characterization of isomeric glycan structures by LC‐MS/MS

L Veillon, Y Huang, W Peng, X Dong, BG Cho… - …, 2017 - Wiley Online Library
The characterization of glycosylation is critical for obtaining a comprehensive view of the
regulation and functions of glycoproteins of interest. Due to the complex nature of …

Recent advances in the analysis of complex glycoproteins

S Gaunitz, G Nagy, NLB Pohl, MV Novotny - Analytical chemistry, 2017 - ACS Publications
Notes 408 Biographies 408 Acknowledgments 409 References 409 The enormous
structural diversity of glycoconjugates mirrors their myriad biological functions in prokaryotic …

Isomeric separation of permethylated glycans by porous graphitic carbon (PGC)-LC-MS/MS at high temperatures

S Zhou, Y Huang, X Dong, W Peng, L Veillon… - Analytical …, 2017 - ACS Publications
Permethylation is a common derivatization method for MS-based glycomic analyses.
Permethylation enhances glycan ionization efficiency in positive MS analysis and improves …

LC-MS/MS analysis of permethylated N-glycans facilitating isomeric characterization

S Zhou, X Dong, L Veillon, Y Huang… - Analytical and bioanalytical …, 2017 - Springer
The biosynthesis of glycans is a template-free process; hence compositionally identical
glycans may contain highly heterogeneous structures. Meanwhile, the functions of glycans …

The dynamic brain N-glycome

TS Klarić, G Lauc - Glycoconjugate journal, 2022 - Springer
The attachment of carbohydrates to other macromolecules, such as proteins or lipids, is an
important regulatory mechanism termed glycosylation. One subtype of protein glycosylation …

LC‐MS/MS analysis of permethylated free oligosaccharides and N‐glycans derived from human, bovine, and goat milk samples

X Dong, S Zhou, Y Mechref - Electrophoresis, 2016 - Wiley Online Library
Oligosaccharides in milk not only provide nutrition to the infants but also have significant
immune biofunctions such as inhibition of pathogen binding to the host cell. The main …

Imaging of N-linked glycans from formalin-fixed paraffin-embedded tissue sections using MALDI mass spectrometry

S Toghi Eshghi, S Yang, X Wang, P Shah… - ACS chemical …, 2014 - ACS Publications
Aberrant glycosylation is associated with most of the diseases. Direct imaging and profiling
of N-glycans on tissue sections can reveal tissue-specific and/or disease-associated N …

MS-based glycomics: An analytical tool to assess nervous system diseases

W Peng, F Kobeissy, S Mondello, C Barsa… - Frontiers in …, 2022 - frontiersin.org
Neurological diseases affect millions of peopleochemistryorldwide and are continuously
increasing due to the globe's aging population. Such diseases affect the nervous system …

MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney

OJR Gustafsson, MT Briggs, MR Condina… - Analytical and …, 2015 - Springer
Recent developments in spatial proteomics have paved the way for retrospective in situ
mass spectrometry (MS) analyses of formalin-fixed paraffin-embedded clinical tissue …

Characterization of N-glycome profile in mouse brain tissue regions by MALDI-TOF/MS

Y Liu, Y Han, W Zhu, Q Luo, J Yuan, X Liu - Analytical and Bioanalytical …, 2023 - Springer
Glycosylation is one of the most common types of post-translational modifications in
mammals. It is well known that N-glycans play a key role in cell adhesion, differentiation …