Shedding more light on the role of Midkine in hepatocellular carcinoma: New perspectives on diagnosis and therapy
A Gowhari Shabgah, F Ezzatifar, S Aravindhan… - IUBMB …, 2021 - Wiley Online Library
One of the most common malignant tumors is hepatocellular carcinoma (HCC). Progression
of HCC mainly results from highly complex molecular and pathological pathways. Midkine …
of HCC mainly results from highly complex molecular and pathological pathways. Midkine …
[HTML][HTML] Biomarker discovery and application—an opportunity to resolve the challenge of liver cancer diagnosis and treatment
J Chen, C Niu, N Yang, C Liu, S Zou, S Zhu - Pharmacological Research, 2023 - Elsevier
Liver cancer is one of the most common malignancies, with severe morbidity and mortality.
While considerable progress has been made in liver cancer treatment, the 5-year overall …
While considerable progress has been made in liver cancer treatment, the 5-year overall …
Single-cell transcriptomic analysis suggests two molecularly distinct subtypes of intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is a highly heterogeneous cancer with limited
understanding of its classification and tumor microenvironment. Here, by performing single …
understanding of its classification and tumor microenvironment. Here, by performing single …
Transcriptome‐level discovery of survival‐associated biomarkers and therapy targets in non‐small‐cell lung cancer
B Győrffy - British Journal of Pharmacology, 2024 - Wiley Online Library
Abstract Background and Purpose Survival rate of patients with lung cancer has increased
by over 60% in the recent two decades. With longer survival, the identification of genes …
by over 60% in the recent two decades. With longer survival, the identification of genes …
[HTML][HTML] Midkine as a driver of age-related changes and increase in mammary tumorigenesis
Aging is a pivotal risk factor for cancer, yet the underlying mechanisms remain poorly
defined. Here, we explore age-related changes in the rat mammary gland by single-cell …
defined. Here, we explore age-related changes in the rat mammary gland by single-cell …
[HTML][HTML] Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain
Interactions between angiogenesis and neurogenesis regulate embryonic brain
development. However, a comprehensive understanding of the stages of vascular cell …
development. However, a comprehensive understanding of the stages of vascular cell …
Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
Abstract mTORC1 is hyperactive in multiple cancer types,. Here, we performed integrative
analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and …
analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and …
[HTML][HTML] Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment
To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis
1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas …
1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas …
Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis
N Mohammadi Ghahhari, MK Sznurkowska… - Nature …, 2022 - nature.com
The epithelial to mesenchymal transition (EMT) has been proposed to contribute to the
metastatic spread of breast cancer cells. EMT-promoting transcription factors determine a …
metastatic spread of breast cancer cells. EMT-promoting transcription factors determine a …
Tumour evolution and microenvironment interactions in 2D and 3D space
To study the spatial interactions among cancer and non-cancer cells 1, we here examined a
cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial …
cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial …