Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Chromatin is organized into higher-order structures that form subcompartments in
interphase nuclei. Different categories of specialized enzymes act on chromatin and …

Since the discovery of SUMO twenty years ago, SUMO conjugation has become a widely
recognized post-translational modification that targets a myriad of proteins in many …

The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is
essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51 …

Nuclear actin has been implicated in a variety of DNA-related processes including chromatin
remodeling, transcription, replication, and DNA repair. However, the mechanistic …

Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …

Post-translational modification by Small Ubiquitin-like Modifier (SUMO) proteins regulates
numerous cellular processes. This modification involves the covalent and reversible …

The nucleus is a dynamic environment containing chromatin, membraneless organelles,
and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA …

The accessibility of eukaryotic genomes to the action of enzymes involved in transcription,
replication and repair is maintained despite the organization of DNA into nucleosomes. This …

Mutations in the telomere-binding protein POT1 are associated with solid tumors and
leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation …