The striatum: where skills and habits meet
AM Graybiel, ST Grafton - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
After more than a century of work concentrating on the motor functions of the basal ganglia,
new ideas have emerged, suggesting that the basal ganglia also have major functions in …
new ideas have emerged, suggesting that the basal ganglia also have major functions in …
[HTML][HTML] Striatal synaptic adaptations in Parkinson's disease
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
[HTML][HTML] Dopamine is required for the neural representation and control of movement vigor
Progressive depletion of midbrain dopamine neurons (PDD) is associated with deficits in the
initiation, speed, and fluidity of voluntary movement. Models of basal ganglia function focus …
initiation, speed, and fluidity of voluntary movement. Models of basal ganglia function focus …
Striatal synapses, circuits, and Parkinson's disease
Highlights•Homeostatic plasticity plays an important role in mitigating striatal
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …
Dopaminergic modulation of striatal function and Parkinson's disease
The striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a
diverse array of cellular and synaptic functions that control goal-directed actions and habits …
diverse array of cellular and synaptic functions that control goal-directed actions and habits …
Inversely active striatal projection neurons and interneurons selectively delimit useful behavioral sequences
Understanding neural representations of behavioral routines is critical for understanding
complex behavior in health and disease. We demonstrate here that accentuated activity of …
complex behavior in health and disease. We demonstrate here that accentuated activity of …
Pallidostriatal projections promote β oscillations in a dopamine-depleted biophysical network model
VL Corbit, TC Whalen, KT Zitelli, SY Crilly… - Journal of …, 2016 - Soc Neuroscience
In the basal ganglia, focused rhythmicity is an important feature of network activity at certain
stages of motor processing. In disease, however, the basal ganglia develop amplified …
stages of motor processing. In disease, however, the basal ganglia develop amplified …
The origin of abnormal beta oscillations in the parkinsonian corticobasal ganglia circuits
Parkinson's disease (PD) is a neurodegenerative brain disorder associated with motor and
nonmotor symptoms. Exaggerated beta band (15–30 Hz) neuronal oscillations are widely …
nonmotor symptoms. Exaggerated beta band (15–30 Hz) neuronal oscillations are widely …
Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents
M Xia, BN Agca, T Yoshida, J Choi, U Amjad… - Biosensors and …, 2023 - Elsevier
We developed a flexible “electrode-thread” array for recording dopamine neurochemicals
from a lateral distribution of subcortical targets (up to 16) transverse to the axis of insertion …
from a lateral distribution of subcortical targets (up to 16) transverse to the axis of insertion …
Striatal cholinergic interneurons and cortico‐striatal synaptic plasticity in health and disease
M Deffains, H Bergman - Movement Disorders, 2015 - Wiley Online Library
Basal ganglia disorders such as Parkinson's disease, dystonia, and Huntington's disease
are characterized by a dysregulation of the basal ganglia neuromodulators (dopamine …
are characterized by a dysregulation of the basal ganglia neuromodulators (dopamine …