beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

Alzheimer's disease is a progressive neurodegenerative disorder characterised by the
gradual onset of dementia. The pathological hallmarks of the disease are β‐amyloid (Aβ) …

Inherited disorders of hemostasis are natural models for investigating mechanisms of
thrombosis and development of antithrombotic therapy. Because mice with total factor XI …

Calcium is a key mediator controlling essential neuronal functions depending on electrical
activity. Altered neuronal calcium homeostasis affects metabolism of amyloid precursor …

Enolase enzymes are abundantly expressed, cytosolic carbon‐oxygen lyases known for
their role in glucose metabolism. Recently, enolase has been shown to possess a variety of …

Alzheimer's disease is characterized by the accumulation of beta amyloid peptides in
plaques and vessel walls and by the intraneuronal accumulation of paired helical filaments …

Peripheral biomarkers play an indispensable role in quick and reliable diagnoses of any
kind of disease. With the population ageing, the number of people suffering from age-related …

Alzheimer Disease (AD) is the most common neurodegenerative disorder worldwide, and
account for 60% to 70% of all cases of progressive cognitive impairment in elderly patients …

The amyloid precursor protein (APP), primarily known as the precursor of amyloid peptides
that accumulate in the brain of patients with Alzheimer disease, is abundant in platelets, but …

The proteolytic processing of amyloid precursor protein (APP) through the formation of
membrane-bound C-terminal fragments (CTFs) and of soluble β-amyloid peptides likely …