WNT signaling in tumors: the way to evade drugs and immunity
E Martin-Orozco, A Sanchez-Fernandez… - Frontiers in …, 2019 - frontiersin.org
WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …
embryonic development, cell migration, and polarization has been shown. Nevertheless …
CD44, hyaluronan, the hematopoietic stem cell, and leukemia-initiating cells
M Zoeller - Frontiers in immunology, 2015 - frontiersin.org
CD44 is an adhesion molecule that varies in size due to glycosylation and insertion of so-
called variant exon products. The CD44 standard isoform (CD44s) is highly expressed in …
called variant exon products. The CD44 standard isoform (CD44s) is highly expressed in …
Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells
The canonical wingless-type MMTV integration site (WNT)-β-catenin pathway is essential for
self-renewal, growth and survival of acute myeloid leukemia (AML) stem/blast progenitor …
self-renewal, growth and survival of acute myeloid leukemia (AML) stem/blast progenitor …
Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia
X Jiang, PY Mak, H Mu, W Tao, DH Mak… - Clinical Cancer …, 2018 - AACR
Purpose: Wnt/β-catenin signaling is required for leukemic stem cell function. FLT3 mutations
are frequently observed in acute myeloid leukemia (AML). Anomalous FLT3 signaling …
are frequently observed in acute myeloid leukemia (AML). Anomalous FLT3 signaling …
Understanding of leukemic stem cells and their clinical implications
X Wang, S Huang, JL Chen - Molecular cancer, 2017 - Springer
Since leukemic stem cells (LSCs) or cancer stem cells (CSCs) were found in acute myeloid
leukemia (AML) in 1997, extensive studies have been contributed to identification and …
leukemia (AML) in 1997, extensive studies have been contributed to identification and …
Wnt signaling in hematological malignancies
S Grainger, D Traver, K Willert - Progress in molecular biology and …, 2018 - Elsevier
Leukemia and lymphoma are a wide encompassing term for a diverse set of blood
malignancies that affect people of all ages and result in approximately 23,000 deaths in the …
malignancies that affect people of all ages and result in approximately 23,000 deaths in the …
SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome
H Alachkar, R Santhanam, K Maharry… - The Journal of …, 2014 - Am Soc Clin Investig
Aberrant expression of the secreted protein, acidic, cysteine-rich (osteonectin)(SPARC)
gene, which encodes a matricellular protein that participates in normal tissue remodeling, is …
gene, which encodes a matricellular protein that participates in normal tissue remodeling, is …
[HTML][HTML] Beyond leukotriene formation—The noncanonical functions of 5-lipoxygenase
AK Häfner, AS Kahnt, D Steinhilber - Prostaglandins & other lipid mediators, 2019 - Elsevier
lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes and specialized
proresolving lipid mediators (SPM). It is mainly expressed in leukocytes and is part of the …
proresolving lipid mediators (SPM). It is mainly expressed in leukocytes and is part of the …
γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin
RG Morgan, L Pearn, K Liddiard, SL Pumford… - Leukemia, 2013 - nature.com
Canonical Wnt signaling regulates the transcription of T-cell factor (TCF)-responsive genes
through the stabilization and nuclear translocation of the transcriptional co-activator, β …
through the stabilization and nuclear translocation of the transcriptional co-activator, β …
Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
J Roos, S Grösch, O Werz, P Schröder, S Ziegler… - Pharmacology & …, 2016 - Elsevier
Canonical Wnt signaling is a highly conserved pathway with a prominent role in
embryogenic development, adult tissue homeostasis, cell polarization, stem cell biology, cell …
embryogenic development, adult tissue homeostasis, cell polarization, stem cell biology, cell …