WNT signaling in tumors: the way to evade drugs and immunity

E Martin-Orozco, A Sanchez-Fernandez… - Frontiers in …, 2019 - frontiersin.org
WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …

CD44, hyaluronan, the hematopoietic stem cell, and leukemia-initiating cells

M Zoeller - Frontiers in immunology, 2015 - frontiersin.org
CD44 is an adhesion molecule that varies in size due to glycosylation and insertion of so-
called variant exon products. The CD44 standard isoform (CD44s) is highly expressed in …

Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells

W Fiskus, S Sharma, S Saha, B Shah, SGT Devaraj… - Leukemia, 2015 - nature.com
The canonical wingless-type MMTV integration site (WNT)-β-catenin pathway is essential for
self-renewal, growth and survival of acute myeloid leukemia (AML) stem/blast progenitor …

Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia

X Jiang, PY Mak, H Mu, W Tao, DH Mak… - Clinical Cancer …, 2018 - AACR
Purpose: Wnt/β-catenin signaling is required for leukemic stem cell function. FLT3 mutations
are frequently observed in acute myeloid leukemia (AML). Anomalous FLT3 signaling …

Understanding of leukemic stem cells and their clinical implications

X Wang, S Huang, JL Chen - Molecular cancer, 2017 - Springer
Since leukemic stem cells (LSCs) or cancer stem cells (CSCs) were found in acute myeloid
leukemia (AML) in 1997, extensive studies have been contributed to identification and …

Wnt signaling in hematological malignancies

S Grainger, D Traver, K Willert - Progress in molecular biology and …, 2018 - Elsevier
Leukemia and lymphoma are a wide encompassing term for a diverse set of blood
malignancies that affect people of all ages and result in approximately 23,000 deaths in the …

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome

H Alachkar, R Santhanam, K Maharry… - The Journal of …, 2014 - Am Soc Clin Investig
Aberrant expression of the secreted protein, acidic, cysteine-rich (osteonectin)(SPARC)
gene, which encodes a matricellular protein that participates in normal tissue remodeling, is …

[HTML][HTML] Beyond leukotriene formation—The noncanonical functions of 5-lipoxygenase

AK Häfner, AS Kahnt, D Steinhilber - Prostaglandins & other lipid mediators, 2019 - Elsevier
lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes and specialized
proresolving lipid mediators (SPM). It is mainly expressed in leukocytes and is part of the …

γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin

RG Morgan, L Pearn, K Liddiard, SL Pumford… - Leukemia, 2013 - nature.com
Canonical Wnt signaling regulates the transcription of T-cell factor (TCF)-responsive genes
through the stabilization and nuclear translocation of the transcriptional co-activator, β …

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

J Roos, S Grösch, O Werz, P Schröder, S Ziegler… - Pharmacology & …, 2016 - Elsevier
Canonical Wnt signaling is a highly conserved pathway with a prominent role in
embryogenic development, adult tissue homeostasis, cell polarization, stem cell biology, cell …