[HTML][HTML] SNPs in 3′ UTR miRNA target sequences associated with individual drug susceptibility
E Rykova, N Ershov, I Damarov… - International Journal of …, 2022 - mdpi.com
The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′
untranslated regions (3′ UTRs) of target gene mRNAs represses translation, playing a …
untranslated regions (3′ UTRs) of target gene mRNAs represses translation, playing a …
Machine learning-based quantitative prediction of drug exposure in drug-drug interactions using drug label information
Many machine learning techniques provide a simple prediction for drug-drug interactions
(DDIs). However, a systematically constructed database with pharmacokinetic (PK) DDI …
(DDIs). However, a systematically constructed database with pharmacokinetic (PK) DDI …
A systematic review and meta-analysis recite the efficacy of Tacrolimus treatment in renal transplant patients in association with genetic variants of CYP3A5 gene
PM Chauhan, RJ Hemani, ND Solanki… - American Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Tacrolimus is an immunosuppressant with a narrow therapeutic index and pharmacokinetic
variability. This variability may be attributed to genetic variants in gene CYP3A5 associated …
variability. This variability may be attributed to genetic variants in gene CYP3A5 associated …
CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver …
Y Dong, Q Xu, R Li, Y Tao, Q Zhang, J Li, Z Ma, C Shen… - Gene, 2022 - Elsevier
Aim The purpose of this study was to investigate the effect of CYP3A7, CYP3A4, and
CYP3A5 genetic polymorphisms in liver transplant recipients and donors on tacrolimus …
CYP3A5 genetic polymorphisms in liver transplant recipients and donors on tacrolimus …
Pharmacogenomics of old and new immunosuppressive drugs for precision medicine in kidney transplantation
S Turolo, A Edefonti, ML Syren, G Montini - Journal of Clinical Medicine, 2023 - mdpi.com
Kidney transplantation is the preferred therapeutic option for end-stage kidney disease, but,
despite major therapeutic advancements, allograft rejection continues to endanger graft …
despite major therapeutic advancements, allograft rejection continues to endanger graft …
An integrated clinical and genetic prediction model for tacrolimus levels in pediatric solid organ transplant recipients
S Min, T Papaz, AN Lambert, U Allen, P Birk… - …, 2022 - journals.lww.com
Background. There are challenges in achieving and maintaining therapeutic tacrolimus
levels after solid organ transplantation (SOT). The purpose of this genome-wide association …
levels after solid organ transplantation (SOT). The purpose of this genome-wide association …
Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese …
G Qi, C Han, Y Zhou, X Wang - Clinical and Experimental …, 2022 - Wiley Online Library
Over 50% prescribed drugs are metabolised by cytochrome P450 3A (CYP3A) and
glutathione S‐transferase pi (GSTP1) adds a glutathione to the oxidative products by …
glutathione S‐transferase pi (GSTP1) adds a glutathione to the oxidative products by …
Synergistic Effect of Cytochrome P450 Family 3 Subfamily A Member 5 (CYP3A5) Genetic Variants in Tacrolimus Dose Determination in Indian Renal Transplant …
RJ Hemani, PM Chauhan, R Srivastava… - ACS Pharmacology & …, 2024 - ACS Publications
Tacrolimus (TAC) has a narrow therapeutic index and shows interindividual variabilities in
its blood concentration. Although guidelines recommend a genetic variant (rs776746) to …
its blood concentration. Although guidelines recommend a genetic variant (rs776746) to …
Whole‐exome sequencing analysis in 10 families of sporadic microtia with thoracic deformities
M Yang, X Lu, Y Zhang, C Wang, Z Cai… - … Genetics & Genomic …, 2021 - Wiley Online Library
Background Microtia is a congenital malformation of the external ear and may occur as an
isolated deformity or as part of a syndrome. Our previous study found a high correlation …
isolated deformity or as part of a syndrome. Our previous study found a high correlation …
Unraveling the genomic architecture of the CYP3A locus and ADME genes for personalized tacrolimus dosing
Background. Tacrolimus (TAC) is an immunosuppressant widely prescribed following an
allogenic organ transplant. Due to wide interindividual pharmacokinetic (PK) variability …
allogenic organ transplant. Due to wide interindividual pharmacokinetic (PK) variability …