Mathematical modeling of oncolytic virus therapy reveals role of the immune response
E Guo, HM Dobrovolny - Viruses, 2023 - mdpi.com
Oncolytic adenoviruses (OAds) present a promising path for cancer treatment due to their
selectivity in infecting and lysing tumor cells and their ability to stimulate the immune …
selectivity in infecting and lysing tumor cells and their ability to stimulate the immune …
Survivin silencing and TRAIL expression using oncolytic adenovirus increase anti-tumorigenic activity in gemcitabine-resistant pancreatic cancer cells
Z Han, S Lee, S Je, CY Eom, HJ Choi, JJ Song, JH Kim - Apoptosis, 2016 - Springer
In this study, we demonstrated that survivin downregulation with TRAIL expression greatly
enhanced the cytotoxic death of pancreatic cancer cells after gemcitabine treatment. Using …
enhanced the cytotoxic death of pancreatic cancer cells after gemcitabine treatment. Using …
[HTML][HTML] Prime-boost immunization by both DNA vaccine and oncolytic adenovirus expressing GM-CSF and shRNA of TGF-β2 induces anti-tumor immune activation
SY Kim, D Kang, HJ Choi, Y Joo, JH Kim, JJ Song - Oncotarget, 2017 - ncbi.nlm.nih.gov
A successful DNA vaccine for the treatment of tumors should break established immune
tolerance to tumor antigen. However, due to the relatively low immunogenicity of DNA …
tolerance to tumor antigen. However, due to the relatively low immunogenicity of DNA …
Cell-surface integrins and CAR are both essential for adenovirus type 5 transduction of canine cells of lymphocytic origin
Adenoviruses are the most widely used vectors in cancer gene therapy. Adenoviruses
vectors are well characterized and are easily manipulated. Adenovirus serotype 5 (Ad5) is …
vectors are well characterized and are easily manipulated. Adenovirus serotype 5 (Ad5) is …
Enhanced tumor targeting and timely viral release of mesenchymal stem cells/oncolytic virus complex due to GRP78 and inducible E1B55K expressions greatly …
S Choi, JA Hong, HJ Choi, JJ Song - Molecular Therapy-Oncolytics, 2022 - cell.com
Systemic delivery of oncolytic viruses has been widely regarded as an impractical option for
antitumor treatment. Here, we selected two target genes as leading components, and …
antitumor treatment. Here, we selected two target genes as leading components, and …
Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents
Background Virotherapy represents a promising approach for ovarian cancer. In this regard,
conditionally replicative adenovirus (CRAd) has been translated to the context of human …
conditionally replicative adenovirus (CRAd) has been translated to the context of human …
[PDF][PDF] Mathematical Modeling of Oncolytic Virus Therapy Reveals Role of the Immune Response. Viruses 2023, 15, 1812
E Guo, HM Dobrovolny - 2023 - researchgate.net
Oncolytic adenoviruses (OAds) present a promising path for cancer treatment due to their
selectivity in infecting and lysing tumor cells and their ability to stimulate the immune …
selectivity in infecting and lysing tumor cells and their ability to stimulate the immune …
Temozolomide renders murine cancer cells susceptible to oncolytic adenovirus replication and oncolysis
R Garza-Morales, K Yaddanapudi… - Cancer Biology & …, 2018 - Taylor & Francis
The preclinical evaluation of oncolytic adenoviruses (OAds) has been limited to cancer
xenograft mouse models because OAds replicate poorly in murine cancer cells. The …
xenograft mouse models because OAds replicate poorly in murine cancer cells. The …
High levels of Daxx due to low cellular levels of HSP25 in murine cancer cells result in inefficient adenovirus replication
Z Han, Y Joo, J Lee, S Ko, R Xu, GH Oh… - … & molecular medicine, 2019 - nature.com
When the adenoviral protein E1B55K binds death domain-associated protein (Daxx), the
proteasome-dependent degradation of Daxx is initiated, and adenoviral replication is …
proteasome-dependent degradation of Daxx is initiated, and adenoviral replication is …
Adenovirus Lacking E1b Efficiently Induces Cytopathic Effect in HPV-16-Positive Murine Cancer Cells via Virus Replication and Apoptosis
E Martinez-Jaramillo, R Garza-Morales… - Cancer …, 2018 - Taylor & Francis
Conditionally replicative adenoviruses (CRAds) replicate poorly in murine cancer cells;
however, E1b-deleted CRAds may replicate effectively in HPV16-E6/E7-positive murine …
however, E1b-deleted CRAds may replicate effectively in HPV16-E6/E7-positive murine …