The role of ubiquitination in tumorigenesis and targeted drug discovery
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
The role of ubiquitination and deubiquitination in cancer metabolism
T Sun, Z Liu, Q Yang - Molecular cancer, 2020 - Springer
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc
J Tang, T Yan, Y Bao, C Shen, C Yu, X Zhu… - Nature …, 2019 - nature.com
Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role
of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In …
of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In …
Alternative approaches to target Myc for cancer treatment
The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …
MYC degradation
AS Farrell, RC Sears - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
The MYC oncoprotein is an essential transcription factor that regulates the expression of
many genes involved in cell growth, proliferation, and metabolic pathways. Thus, it is …
many genes involved in cell growth, proliferation, and metabolic pathways. Thus, it is …
[HTML][HTML] Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment
S Yang, H Xiao, L Cao - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones,
which participate in protein folding and maturation in response to stresses or high …
which participate in protein folding and maturation in response to stresses or high …
A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity
Targeting sirtuins for cancer treatment has been a topic of debate due to conflicting reports
and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine …
and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine …
E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer
H Wang, W Yang, Q Qin, X Yang, Y Yang, H Liu, W Lu… - Molecular cancer, 2022 - Springer
Background Recurrence and chemoresistance constitute the leading cause of death in
colorectal cancer (CRC). Thus, it is of great significance to clarify the underlying …
colorectal cancer (CRC). Thus, it is of great significance to clarify the underlying …
Targeting CSC-related transcription factors by E3 ubiquitin ligases for cancer therapy
W Wang, W Liu, Q Chen, Y Yuan, P Wang - Seminars in Cancer Biology, 2022 - Elsevier
Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …